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"Giorgi" ] 10 => array:2 [ "nombre" => "Manuel Rafael" "apellidos" => "Ramirez Chamond" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2013251418300610" "doi" => "10.1016/j.nefroe.2018.04.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251418300610?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699518300018?idApp=UINPBA000064" "url" => "/02116995/0000003800000003/v2_201810040615/S0211699518300018/v2_201810040615/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S201325141830052X" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2018.03.005" "estado" => "S300" "fechaPublicacion" => "2018-05-01" "aid" => "402" "copyright" => "Sociedad Española de 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"contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1859 "Ancho" => 2500 "Tamanyo" => 995561 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Medication analyzed: ESA, ACE inhibitors, statins, antiaggregants, anticoagulants, sevelamer, calcium containing phosphate binders, cinacalcet, lanthanum.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The intake of calcium containing phosphate binders was greater in patients with QA-C <600<span class="elsevierStyleHsp" style=""></span>ml/min than >600<span class="elsevierStyleHsp" style=""></span>ml/min. These differences are accentuated in the subgroup of patients aged >75 years. In the rest of the medication analyzed no significant differences were found.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">ESA: erythropoietin stimulating agents; ACE inhibitors: angiotensin-converting enzyme inhibitors; Lanthanum: lanthanum carbonate.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Enoc Merino García, M. José García Cortés, M. Mar Biechy Baldán, Sonia Ortega Anguiano, Manuel Polaina Rusillo, M. Carmen Sánchez Perales" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Enoc" "apellidos" => "Merino García" ] 1 => array:2 [ "nombre" => "M. José" "apellidos" => "García Cortés" ] 2 => array:2 [ "nombre" => "M. Mar" "apellidos" => "Biechy Baldán" ] 3 => array:2 [ "nombre" => "Sonia" "apellidos" => "Ortega Anguiano" ] 4 => array:2 [ "nombre" => "Manuel" "apellidos" => "Polaina Rusillo" ] 5 => array:2 [ "nombre" => "M. 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Martínez Miguel, Lourdes Bohorquez, Patricia de Sequera, Hanane Bouarich, Rafael Pérez-García, Diego Rodríguez Puyol, Guillermina Barril, Jose Antonio Sánchez Tomero, Martin Giorgi, Manuel Rafael Ramirez Chamond" "autores" => array:11 [ 0 => array:4 [ "nombre" => "Marta" "apellidos" => "Albalate Ramón" "email" => array:1 [ 0 => "malbalater@senefro.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Patricia" "apellidos" => "Martínez Miguel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Lourdes" "apellidos" => "Bohorquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Patricia" "apellidos" => "de Sequera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Hanane" "apellidos" => "Bouarich" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Rafael" "apellidos" => "Pérez-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Diego" "apellidos" => "Rodríguez Puyol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "Guillermina" "apellidos" => "Barril" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 8 => array:3 [ "nombre" => "Jose Antonio" "apellidos" => "Sánchez Tomero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 9 => array:3 [ "nombre" => "Martin" "apellidos" => "Giorgi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 10 => array:3 [ "nombre" => "Manuel Rafael" "apellidos" => "Ramirez Chamond" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Infanta Leonor, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Laboratorio de Fisiología, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital de La Princesa, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El triacetato de celulosa asimétrico es una alternativa segura y eficaz para la hemodiafiltración en línea" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Online haemodiafiltration (OLHDF) is the most complete haemodialysis technique currently available, as it is capable of removing significant quantities of low-, medium- and high-molecular weight uraemic toxins, in direct relation with the convective transport volume obtained.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Post-dilution OLHDF is the most used form and has proven efficacy. It is known to be a safe technique which improves intradialytic haemodynamic tolerance and increases survival.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2–4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">OLHDF uses high-flux biocompatible dialysers, providing greater clearance per unit of surface by combining the processes of diffusion and convection. To date, the membranes used in this technique have been synthetic. In the study by Maduell et al.,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> in which multiple dialysers for OLHDF were compared, they considered that cellulose triacetate had a low purification of β<span class="elsevierStyleInf">2</span>-microglobulin and limited its use in OLHDF due to high transmembrane pressure (TMP). An asymmetric cellulose triacetate membrane (ATA<span class="elsevierStyleSup">®</span>) was recently marketed in the Solacea<span class="elsevierStyleSup">®</span> (Nipro) dialyser with a KUF of 72<span class="elsevierStyleHsp" style=""></span>ml/mmHg/h/m<span class="elsevierStyleSup">2</span> and configured in order to perform OLHDF. In accordance with the manufacturer's data, the complement activation produced is similar to that of the synthetic membranes, demonstrating its biocompatibility. Its long-term biocompatibility through its effect on monocytes and interleukins (IL) is still to be determined. As yet, there is no publication on the convective volume (Vconv) obtained, the adaptation to different OLHDF systems, the clearance capacity for different types of molecules or biocompatibility in daily clinical practice. The recent description of various cases of hypersensitivity with biocompatible membranes, such as polysulfone,<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> in which cellulose triacetate is used as an alternative, has led to even greater interest in the study of this type of membrane.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Objective</span><p id="par0015" class="elsevierStylePara elsevierViewall">To describe the features and the <span class="elsevierStyleItalic">in vivo</span> behaviour of the ATA<span class="elsevierStyleSup">®</span> membrane in order to identify: its clearance efficacy, biocompatibility and ease of use in clinical practice.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Material and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">This was a prospective, observational study in three hospital haemodialysis units (Hospital de La Princesa, Hospital Príncipe de Asturias and Hospital Infanta Leonor, Autonomous Community of Madrid, Spain) in which the normal synthetic dialyser that each patient had for OLHDF was replaced with an ATA<span class="elsevierStyleSup">®</span> dialyser, with all other parameters remaining the same. The study (LIB 09/2015) was reviewed and approved by the Hospital Universitario Príncipe de Asturias IEC (Alcalá de Henares, Madrid).</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Inclusion and exclusion criteria</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Inclusion criteria:</span> over 18 years of age, having undergone treatment with OLHDF for more than four weeks (with three weekly sessions) and having signed the informed consent form.</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Exclusion criteria:</span> pregnancy and illness which means that death is predicted to occur in fewer than four weeks.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Study design</span><p id="par0035" class="elsevierStylePara elsevierViewall">Each patient underwent 12 haemodialysis sessions (during one month) with his/her normal regimen of time, bathing, heparin dose, sodium and bicarbonate conductivity and also on his/her normal monitor: 5008-Fresenius<span class="elsevierStyleSup">®</span> (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14), AK 200-Gambro<span class="elsevierStyleSup">®</span> (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5), Artis-Gambro<span class="elsevierStyleSup">®</span> (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3) and the Nikkiso DBB-07 (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1). All monitors were suitable for conducting OLHDF, although with different automated control systems for convective transport. The Qb used was the maximum facilitated vascular access, without allowing an arterial line the pressure below −220<span class="elsevierStyleHsp" style=""></span>mmHg.</p><p id="par0040" class="elsevierStylePara elsevierViewall">In all cases, the nursing staff connected the automated OLHDF system to the system with which the patient's monitor operated. In the event that the system was Ultracontrol<span class="elsevierStyleSup">®</span>, the warning systems were set at TMP<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>300 or pressure system (Psyst)<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>700<span class="elsevierStyleHsp" style=""></span>mmHg. In the event that these warnings were shown and not resolved, Ultracontrol<span class="elsevierStyleSup">®</span> would be withdrawn and the control-pressure system would be used, in which the TMP remains at values which ensure a Psyst<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>700<span class="elsevierStyleHsp" style=""></span>mmHg and an appropriate infusion volume (Vinf).</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Dialyser features</span><p id="par0045" class="elsevierStylePara elsevierViewall">The features of the dialyser are specified in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Data collected</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Demographic and dialysis data</span><p id="par0050" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall">Demographic data: gender, age, underlying disease, time on OLHDF, type of vascular access: fistula or catheter.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">General information related to the dialysis procedure: monitor, composition of dialysis fluid (calcium, potassium) sodium and bicarbonate conductivities, dialysis fluid flow (Qd, ml/min), fluid temperature, type and dose of heparin.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">In each dialysis session: effective time (min), blood flow (Qb, ml/min), volume ultrafiltrated to achieve dry weight (UF, l/session), Vinf (l/session), infusion rate (Qi, ml/min), Kt (l/session), maximum TMP and maximum Psyst in Ultracontrol<span class="elsevierStyleSup">®</span> (mmHg) and the technical complications, warnings and system coagulation problems that could occur.</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">The filtration fraction (FF) was calculated as the percentage of Qi relative to Qb. Following the definition of the EuDial group, the Vconv was defined as the total ultrafiltrate volume, which is the sum of Vinf and UF.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Blood tests</span><p id="par0075" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">Pre-dialysis samples were obtained on the first and last day to measure monocytes and IL-6 and IL-1β.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0085" class="elsevierStylePara elsevierViewall">On the mid day of the first week, three blood extractions were performed: the first, at the start (CI); the second, after 30<span class="elsevierStyleHsp" style=""></span>min (CM), and the third, at the end of the dialysis session (CP). All from the arterial line: the first directly from the patient, before the connection, and the other two after reduction of Qb to 50<span class="elsevierStyleHsp" style=""></span>ml/min. during one minute.</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">The following were measured at CI and CP: blood count; proteins and albumin; small molecules (molecular weight less than 500<span class="elsevierStyleHsp" style=""></span>Da): urea (60<span class="elsevierStyleHsp" style=""></span>Da), phosphorus (95<span class="elsevierStyleHsp" style=""></span>Da), creatinine (113<span class="elsevierStyleHsp" style=""></span>Da) and uric acid (168<span class="elsevierStyleHsp" style=""></span>Da); medium molecules (molecular weight greater than 500<span class="elsevierStyleHsp" style=""></span>Da): β<span class="elsevierStyleInf">2</span>-microglobulin (11,818<span class="elsevierStyleHsp" style=""></span>Da) and myoglobin (17,200<span class="elsevierStyleHsp" style=""></span>Da); and molecules bound to proteins: retinol-binding protein (21,200<span class="elsevierStyleHsp" style=""></span>Da).</p><p id="par0095" class="elsevierStylePara elsevierViewall">Leukocytes, platelets, C3a and C5a were measured to study acute biocompatibility at CI and CM.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Laboratory methods</span><p id="par0100" class="elsevierStylePara elsevierViewall">General biochemical data: blood count, proteins, albumin, urea, phosphorus, creatinine (113<span class="elsevierStyleHsp" style=""></span>Da), uric acid, β<span class="elsevierStyleInf">2</span>-microglobulin, myoglobin and retinol-binding protein were determined with each hospital's regular analyser.</p><p id="par0105" class="elsevierStylePara elsevierViewall">The determinations of monocytes, C3a, C5a, IL-6 and IL-1β were performed at the Universidad de Alcalá laboratory. C3a and C5a were measured with the ELISA Kit C3a Elabscience (Wuhan, PR China) and ELISA C5a RayBiotech (Norcross, GA, USA). The concentration of IL-6 and IL-1β was measured in frozen serum samples with Abcam kits (Cambridge, United Kingdom). The populations of monocytes were identified by flow cytometry (FACSCalibur™, Becton Dickinson, San Jose, CA, USA).</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Calculations</span><p id="par0110" class="elsevierStylePara elsevierViewall">The percent reduction ratios (RR) were calculated with the formula: RR (%)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>[(Cpre<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>Cpos)/Cpre]<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>100, where Cpre and Cpos are the concentrations of the compounds analysed pre- and post-dialysis.</p><p id="par0115" class="elsevierStylePara elsevierViewall">For the substances bound to proteins and the β<span class="elsevierStyleInf">2</span>-microglobulin, the concentrations at the end of the session were corrected for haemoconcentration by a correction factor based on the change in plasma protein concentration:</p><p id="par0120" class="elsevierStylePara elsevierViewall">Correction factor<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>TPpre/TPpos,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a>where TPpre and TPpos are the concentrations of total proteins pre- and post-dialysis.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Statistical analysis</span><p id="par0125" class="elsevierStylePara elsevierViewall">All the information was collected in a database file to be analysed using SPPS <span class="elsevierStyleItalic">vs</span> .15. Each value was the mean of the values obtained from the different sessions or blood determinations.</p><p id="par0130" class="elsevierStylePara elsevierViewall">For the statistical analysis, descriptive statistics included means (standard deviation), median with quartiles or percentages, as appropriate. Paired Student's <span class="elsevierStyleItalic">t</span>-test was used to compare paired measurements from continuous variables. <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 was considered to be statistically significant.</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Results</span><p id="par0135" class="elsevierStylePara elsevierViewall">The study included 23 patients (15 males, 8 females) with a median age of 65 (41–85). The causes of kidney disease were: diabetic nephropathy in seven cases, glomerular disease in six cases, nephroangiosclerosis in two cases, reduced kidney mass in two cases, hepatorenal polycystic disease in two cases, chronic pyelonephritis in one case and unknown origin in three cases. The median time on renal replacement therapy was 98 (17–315) months. Sixteen patients had arteriovenous fistula and seven had a catheter. The mean dry weight was 73.4 (16.7) kg.</p><p id="par0140" class="elsevierStylePara elsevierViewall">A total of 287 sessions were performed, and 264 complete sessions were collected (sessions excluded were those in which the effective time differed by more than 15<span class="elsevierStyleHsp" style=""></span>min from the scheduled time, or if the monitor had been changed). One patient was lost to follow-up due to vascular disease requiring hospital admission .</p><p id="par0145" class="elsevierStylePara elsevierViewall">The results of dialysis parameters and molecule clearance are shown in <a class="elsevierStyleCrossRefs" href="#tbl0010">Tables 2 and 3</a>, respectively. The FF obtained with the different monitors was: 5008<span class="elsevierStyleSup">®</span> 28.9 (3.9)%, AK 200<span class="elsevierStyleSup">®</span> 31.8 (1.8)%, Artis<span class="elsevierStyleSup">®</span> 32.6 (4)% and DBB-07<span class="elsevierStyleSup">®</span> 27%. There was a negative correlation between the initial Hb and the Vconv (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.5, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>.01) and the Kt (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.5, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01). There were no complications reported and there were no warnings issued by the dialyser and it was not necessary to make changes to the Ultracontrol<span class="elsevierStyleSup">®</span> system. As coagulation problems did not occur the dose of heparin was not changed.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">Finally, <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> lists the acute biocompatibility data while <a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a> shows details on inflammation parameters. Both tables show that there is no complement activation when using a cellulose membrane, and there is not worsening in inflammatory molecules after one month of treatment. There was no significant correlation between CRP and the other inflammatory parameters studied.</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Discussion</span><p id="par0155" class="elsevierStylePara elsevierViewall">Our results show that the membrane studied has the necessary characteristics to perform OLHDF; it obtains a suitable Vconv, Kt and RR for different substances, it does not cause technical problems and nursing work is not affected beyond daily clinical practice. Also, the membrane is biocompatible (it does not activate the complement in the short-term or induce changes in the inflammatory profile in the medium term, based on the data obtained on activation of IL and monocytes).</p><p id="par0160" class="elsevierStylePara elsevierViewall">The two clinical parameters used on a day-to-day basis to assess OLHDF's suitability are Kt and Vconv.<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">9,10</span></a> The mean Kt reached was 56<span class="elsevierStyleHsp" style=""></span>l, this value is greater than the target suggested in the guidelines, and, although the optimal Vconv remains to be decided, a recent study<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> showed that increasing Vconv improves survival linearly between ∼55 and 75<span class="elsevierStyleHsp" style=""></span>l/week; our results indicate that the maximum volume was achieved. The clearance capacity obtained as assessed by RRs for substances of different sizes were also similar to those presented in other studies which feature high-permeability dialysers to perform OLHDF,<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">12,13</span></a> taking into account the differences which may be found depending on the dialysis time and the surface used.</p><p id="par0165" class="elsevierStylePara elsevierViewall">According to the EUDIAL group, the dialyser used to perform OLHDF must have the following features: high flux, ultrafiltration coefficient greater than 20<span class="elsevierStyleHsp" style=""></span>ml/mmHg/h/m<span class="elsevierStyleSup">2</span>, permeability coefficient for β<span class="elsevierStyleInf">2</span>-microglobulin greater than 0.6, and obtain an effective convective transport greater than 20% of the total processed blood.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> Given that each monitor uses different methods to optimise the FF,<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> the results obtained were different depending on which monitor we used, but the results were greater than 27% in all monitors. The classic description of cellulose membranes is that they are thinner than synthetic membranes and have a capillary wall that is uniform and symmetric in composition, without having the necessary resistance to support the high pressures generated in OLHDF.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> However, the ATA<span class="elsevierStyleSup">®</span> membrane is asymmetrical, which allows to have a low TMP and, therefore, to perform OLHDF achieving adequate clearance, in accordance with the measurement parameters used.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Regarding clinical aspects, there were no significant problems in the daily practice, we observed a well adaptation to the different systems which the monitors use to achieve an adequate Vconv, as reflected in the different FFs obtained. This is important fact, since the absence of alarm warnings improves the nurse's work load and means that the dialyser adapts well to the technique.</p><p id="par0175" class="elsevierStylePara elsevierViewall">The idea persists that the contact of these cellulose membranes with blood causes a major inflammatory response, classifying them as non-biocompatible membranes. This inflammatory response could be acute, with complement activation and leukopaenia after 30<span class="elsevierStyleHsp" style=""></span>min of the session, or have consequences in the longer term through activation of monocytes and cytokines. The severity of this response is due to the hydroxyl groups (OH) within the cellulose molecule. The replacement of these groups with acetate has resulted in modified cellulose triacetate membranes which reduce these responses and make them similar to synthetic dialysers. To determine the membrane's acute biocompatibility, complement activation and leukocytes were measured at 30<span class="elsevierStyleHsp" style=""></span>min, and we found reductions similar to the published with synthetic dialysers. This led us to consider this membrane to be biocompatible and the concept that assumes that cellulose as bioincompatible was dismissed.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">There is a great heterogeneity of circulating monocytes in humans. Circulating monocytes which can be summarised as classical and non-classical according to whether they express greater or lower levels of CD14 and CD16 markers. Classical monocytes are most of the monocytes seen in healthy individuals. Non-classical monocyte populations tend are observed in certain pathological situations, such as cardiovascular disease<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a> or inflammatory processes.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> Several studies show a reduction in the percentage of non-classical monocytes and of markers of endothelial damage with OLHDF compared to conventional high-flux haemodialysis.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a> Elevated levels of proinflammatory cytokines have been associated with greater mortality. Our results reveal that these membranes do not induce changes in these inflammatory markers after one month of treatment, as we have not found significant changes in the percentage of non-classical monocytes or in ILs levels. We therefore believe that this substituted cellulose membrane does not induce inflammatory changes different from those of normal synthetic membranes.</p><p id="par0185" class="elsevierStylePara elsevierViewall">Our study has some limitations, although the number of patients is small, but we believe that the number of sessions performed is high and, therefore, the outcome is representative. The objective was not to compare this membrane with other membranes, but instead to describe the membrane it self. Therefore, the design is suitable. Although the number of sessions performed with some monitors, for example the Nikkiso monitor, was lower, we believe that the results are quite conclusive in terms of good adaptation of the filter to all systems. It is yet to be established if there is loss of albumin, which means that there is a question to be answered, however, we do not have the necessary resources to analyse this. We have found one report in which the loss of Albumin is quantified, and it is less than 2<span class="elsevierStyleHsp" style=""></span>g per session.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conclusions</span><p id="par0190" class="elsevierStylePara elsevierViewall">The new ATA<span class="elsevierStyleSup">®</span> membrane obtains adequate Kt and Vconv values, without technical problems. We did not find the classic problems attributed to this type of membrane in the biocompatibility parameters studied, making it possible to perform OLHDF, and finding it to be most useful in patients who are allergic to synthetic membranes.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0195" class="elsevierStylePara elsevierViewall">The study was funded by <span class="elsevierStyleGrantSponsor" id="gs1">Nipro</span>, with a financial contribution of €5000. This was allocated entirely to laboratory expenditure. None of the investigators received payment for the study.</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflicts of interest</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare potential conflicts of interest.</p><p id="par0205" class="elsevierStylePara elsevierViewall">Dr P. de Sequera, Dr M. Albalate and Dr R. Pérez García have participated as speakers at meetings organised by Gambro and Fresenius, and Dr G. Barril has participated at meetings organised by Nikkiso. They charged fees for these talks.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres1026169" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec983881" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1026170" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec983880" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Objective" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Material and methods" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Inclusion and exclusion criteria" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Study design" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Dialyser features" ] 3 => array:3 [ "identificador" => "sec0035" "titulo" => "Data collected" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Demographic and dialysis data" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Blood tests" ] ] ] 4 => array:2 [ "identificador" => "sec0050" "titulo" => "Laboratory methods" ] 5 => array:2 [ "identificador" => "sec0055" "titulo" => "Calculations" ] 6 => array:2 [ "identificador" => "sec0060" "titulo" => "Statistical analysis" ] ] ] 7 => array:2 [ "identificador" => "sec0065" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0070" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0075" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0080" "titulo" => "Funding" ] 11 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflicts of interest" ] 12 => array:2 [ "identificador" => "xack346537" "titulo" => "Acknowledgements" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-07-27" "fechaAceptado" => "2017-11-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec983881" "palabras" => array:5 [ 0 => "Online haemodiafiltration" 1 => "Cellulose triacetate" 2 => "Suitability" 3 => "Biocompatibility" 4 => "Inflammation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec983880" "palabras" => array:5 [ 0 => "Hemodiafiltración en línea" 1 => "Triacetato de celulosa" 2 => "Adecuación" 3 => "Biocompatibilidad" 4 => "Inflamación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In post-dilution haemodiafiltration only synthetic membranes have been used to date. Asymmetric cellulose triacetate (ATA™) is now available, whose characteristics are suitable for this technique.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe the <span class="elsevierStyleItalic">in vivo</span> performance and behaviour of this membrane, to identify its depurative effectiveness, use in clinical practice and its biocompatibility, both acute and after one month of treatment.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Observational prospective study of 23 patients who were dialysed for 4 weeks using an ATA™ membrane and who maintained their prior regimen.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A total of 287 sessions were performed and 264 complete sessions were collected. With an effective time of 243.7 (17.6) min and a mean blood flow of 371.7 (23) ml/min, an average Kt of 56.3 (5.3) l was observed, as well as a convection volume of 27.1 (4.2) l, a filtration fraction of 29.9 (3.7) %, a urea reduction ratio (RR) of 81 (5.2) %, a creatinine RR of 74.7 (4.6) %, a β<span class="elsevierStyleInf">2</span>-microglobulin RR of 76.5 (4.8) % and a retinol binding protein RR of 18.6 (7.6) %. There were no technical problems or alarms. Changing the heparin dosage was not necessary. No increases in C3a or C5a concentrations or leukopenia were observed in the first 30<span class="elsevierStyleHsp" style=""></span>min of the session. Neither the monocyte subpopulations nor IL-β1 or IL-6 were significantly altered after one month of treatment.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The new ATA™ membrane achieves adequate Kt and convection volume, without technical problems and with good biocompatibility and inflammatory profiles. It is therefore a valid option for post-dilution haemodiafiltration, particularly in patients allergic to synthetic membranes.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En la hemodiafiltración posdilucional se han usado solo membranas sintéticas. Ahora contamos con un triacetato de celulosa asimétrico (ATA®) cuyas características lo hacen apto para esta técnica.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Describir las prestaciones y el comportamiento <span class="elsevierStyleItalic">in vivo</span> de esta membrana estudiando la eficacia depurativa y el uso clínico, además de su biocompatibilidad aguda tras un mes de tratamiento.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo observacional en el que se incluyeron 23 pacientes que se dializaron durante 4 semanas con ATA® manteniendo su pauta previa.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se realizaron 287 sesiones y se recogieron 264 sesiones completas. Con un tiempo efectivo de 243,7 (17,6) min y un flujo medio de sangre de 371,7 (23) ml/min, se obtuvo un Kt medio de 56,3 (5,3) l, un volumen convectivo de 27,1 (4,2) l, con una fracción de filtración del 29,9 (3,7) %, un porcentaje de reducción (RR) de urea de 81 (5,2) %, un RR de creatinina de 74,7 (4,6) %, un RR de β<span class="elsevierStyleInf">2</span>-microglobulina de 76,5 (4,8) % y un RR de proteína transportadora de retinol de 18,6 (7,6) %. No se produjeron problemas técnicos ni alarmas. No fue preciso cambiar la dosificación de heparina. A los 30<span class="elsevierStyleHsp" style=""></span>min de la sesión no se produjo ningún aumento de C3a, C5a ni leucopenia. Tampoco se modificaron de forma significativa las poblaciones monocitarias ni la IL-β1 ni IL-6 tras un mes de tratamiento.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">ATA® logra un Kt y un volumen convectivo adecuados, sin problemas técnicos y con buen perfil de biocompatibilidad e inflamatorio, lo que lo convierte en una posibilidad más de tratamiento para hemodiafiltración posdilucional, máxime en pacientes alérgicos a membranas sintéticas.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivos" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Albalate Ramón M, Martínez Miguel P, Bohorquez L, de Sequera P, Bouarich H, Pérez-García R, et al. El triacetato de celulosa asimétrico es una alternativa segura y eficaz para la hemodiafiltración en línea. Nefrologia. 2018;38:315–320.</p>" ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">KUF: ultrafiltration coefficient; Qb: blood flow; Qd: dialysis flow; TMP: transmembrane pressure.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Membrane \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ATA<span class="elsevierStyleSup">®</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sterilisation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Gamma rays \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bisphenol A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">KUF (ml/h/mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Effective surface area (m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Volume (ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">108 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Thickness of membrane (μ) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Length (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">245 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Internal diameter (μ) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">200 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Maximum TMP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">500 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pressure drop (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Qb/Qd (ml/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">200/500 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Blood/fluid \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47/16 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1745878.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Technical features of the Solacea<span class="elsevierStyleSup">®</span> 19H dialyser.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">FF: filtration fraction; Max.TMP: maximum transmembrane pressure; Psyst: system pressure in AK-200; Qb: blood flow; Qd: dialysis flow; Qi: mean infusion rate; SD: standard deviation; <span class="elsevierStyleItalic">T</span>: time; UF: ultrafiltration; VB: blood volume; Vconv: convective volume; Vinf: infusion volume.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Scheduled <span class="elsevierStyleItalic">T</span> (min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">248.7 (17.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Effective <span class="elsevierStyleItalic">T</span> (min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">243.7 (17.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Qb (ml/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">371.7 (23) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Qd (ml/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">553 (128.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VB (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">88.6 (8.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">UF (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.7 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vinf (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.4 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vconv (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27.1 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Qi (ml/min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">111.1 (14.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FF (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.9 (3.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Kt (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.3 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psyst (mmHg) (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">520.6 (58.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Max.TMP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">188.9 (54) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1745880.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Descriptive results of the dialysis sessions (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>264 sessions).</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">β<span class="elsevierStyleInf">2</span>m: β<span class="elsevierStyleInf">2</span>-microglobulin; RBP: retinol-binding protein; RR: reduction ratio.</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">The results are expressed as a mean (standard deviation).</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Urea RR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col">Creatinine RR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col">Myoglobin RR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col">β<span class="elsevierStyleInf">2</span>m RR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col">RBP RR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col">Phosphorus RR \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">81 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">74.7 (4.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">71 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">76.5 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18.6 (7.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">58.1 (45.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1745877.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Descriptive results of molecule clearance (%) (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>22 sessions).</p>" ] ] 3 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">ns: not significant.</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">The results are expressed as a mean (standard deviation).</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Start \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">30<span class="elsevierStyleHsp" style=""></span>min \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leukocytes (×10<span class="elsevierStyleSup">9</span>/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6280 (2552) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6324 (2342) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neutrophils (×10<span class="elsevierStyleSup">9</span>/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3990 (2208) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4210 (2309) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelets (×10<span class="elsevierStyleSup">9</span>/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">191.4 (49.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">176 (44.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C3a (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1160.1 (755.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1511.7 (451.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C5a (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31,260.5 (15,591.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31,524 (13,860.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1745876.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Results on acute biocompatibility with blood samples obtained at the start and after 30<span class="elsevierStyleHsp" style=""></span>min of dialysis (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>22 sessions).</p>" ] ] 4 => array:8 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at5" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">IL-6: interleukin-6; IL-1β: interleukin-1 beta; ns: not significant.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Classical (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Non-classical (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">IL-β1 (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">IL-6 (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Start \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">81.3 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18.6 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.4 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.2 (22.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">End \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">83.5 (8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">16.4 (8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.5 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 (2.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1745879.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Results on monocytes and inflammatory molecules after one month of use (samples obtained before the first session with Solacea<span class="elsevierStyleSup">®</span> and at the start of the last session) (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>21 patients).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0100" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effective removal of protein-bound uraemic solutes by different convective strategies: a prospective trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. 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Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfs530" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "542" "paginaFinal" => "550" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23345621" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0135" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Lesaffer" 1 => "R. de Smet" 2 => "N. Lameire" 3 => "A. Dhondt" 4 => "P. Duym" 5 => "R. 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Canaud" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000346379" "Revista" => array:6 [ "tituloSerie" => "Blood Purif" "fecha" => "2013" "volumen" => "35" "paginaInicial" => "23" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23466374" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0145" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment policy rather than patient characteristics determines convection volume in online postdilution hemodiafiltrations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Chapdelaine" 1 => "I.M. Mostovaya" 2 => "P.J. Blankestijn" 3 => "M.L. Bots" 4 => "M.A. van den Dorpel" 5 => "R. 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Year/Month | Html | Total | |
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2024 October | 50 | 28 | 78 |
2024 September | 35 | 22 | 57 |
2024 August | 74 | 56 | 130 |
2024 July | 92 | 34 | 126 |
2024 June | 52 | 39 | 91 |
2024 May | 57 | 38 | 95 |
2024 April | 62 | 38 | 100 |
2024 March | 44 | 22 | 66 |
2024 February | 51 | 36 | 87 |
2024 January | 32 | 18 | 50 |
2023 December | 31 | 29 | 60 |
2023 November | 50 | 29 | 79 |
2023 October | 36 | 29 | 65 |
2023 September | 39 | 25 | 64 |
2023 August | 39 | 19 | 58 |
2023 July | 55 | 24 | 79 |
2023 June | 53 | 25 | 78 |
2023 May | 59 | 36 | 95 |
2023 April | 33 | 25 | 58 |
2023 March | 83 | 26 | 109 |
2023 February | 61 | 24 | 85 |
2023 January | 53 | 41 | 94 |
2022 December | 75 | 30 | 105 |
2022 November | 74 | 43 | 117 |
2022 October | 138 | 43 | 181 |
2022 September | 69 | 41 | 110 |
2022 August | 107 | 53 | 160 |
2022 July | 93 | 51 | 144 |
2022 June | 82 | 59 | 141 |
2022 May | 113 | 34 | 147 |
2022 April | 182 | 54 | 236 |
2022 March | 146 | 52 | 198 |
2022 February | 142 | 45 | 187 |
2022 January | 102 | 44 | 146 |
2021 December | 94 | 38 | 132 |
2021 November | 107 | 39 | 146 |
2021 October | 117 | 57 | 174 |
2021 September | 226 | 41 | 267 |
2021 August | 46 | 49 | 95 |
2021 July | 61 | 40 | 101 |
2021 June | 65 | 37 | 102 |
2021 May | 87 | 57 | 144 |
2021 April | 152 | 82 | 234 |
2021 March | 53 | 35 | 88 |
2021 February | 46 | 21 | 67 |
2021 January | 43 | 23 | 66 |
2020 December | 55 | 12 | 67 |
2020 November | 37 | 18 | 55 |
2020 October | 54 | 24 | 78 |
2020 September | 44 | 20 | 64 |
2020 August | 60 | 28 | 88 |
2020 July | 42 | 20 | 62 |
2020 June | 43 | 26 | 69 |
2020 May | 64 | 20 | 84 |
2020 April | 37 | 18 | 55 |
2020 March | 40 | 26 | 66 |
2020 February | 79 | 19 | 98 |
2020 January | 78 | 30 | 108 |
2019 December | 80 | 16 | 96 |
2019 November | 71 | 26 | 97 |
2019 October | 62 | 28 | 90 |
2019 September | 56 | 19 | 75 |
2019 August | 28 | 22 | 50 |
2019 July | 36 | 27 | 63 |
2019 June | 49 | 25 | 74 |
2019 May | 57 | 39 | 96 |
2019 April | 72 | 41 | 113 |
2019 March | 43 | 22 | 65 |
2019 February | 28 | 15 | 43 |
2019 January | 49 | 35 | 84 |
2018 December | 170 | 41 | 211 |
2018 November | 369 | 21 | 390 |
2018 October | 263 | 26 | 289 |
2018 September | 135 | 17 | 152 |
2018 August | 47 | 15 | 62 |
2018 July | 60 | 16 | 76 |
2018 June | 94 | 10 | 104 |
2018 May | 63 | 19 | 82 |
2018 April | 12 | 3 | 15 |