Review
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware!
Enfermedad renal asociada con esteroides anabólicos androgénicos y abuso de suplementos vitamínicos: ¡tenga cuidado!
Sérgio Luiz Arruda Parente Filhoa, Pedro Eduardo Andrade de Carvalho Gomesa, Guilherme Aguiar Fortea, Laio Ladislau Lopes Limaa, Geraldo Bezerra da Silva Júniorb, Gdayllon Cavalcante Menesesc, Alice Maria Costa Martinsc, Elizabeth De Francesco Dahera,
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a Medical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil
b Public Health Post-Graduation Program, School of Medicine, Health Sciences Center, University of Fortaleza, Ceará, Brazil
c Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil
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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "26" "paginaFinal" => "31" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sérgio Luiz Arruda Parente Filho, Pedro Eduardo Andrade de Carvalho Gomes, Guilherme Aguiar Forte, Laio Ladislau Lopes Lima, Geraldo Bezerra da Silva Júnior, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins, Elizabeth De Francesco Daher" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Sérgio Luiz Arruda" "apellidos" => "Parente Filho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Pedro Eduardo Andrade de Carvalho" "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Guilherme Aguiar" "apellidos" => "Forte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Laio Ladislau Lopes" "apellidos" => "Lima" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Geraldo Bezerra da" "apellidos" => "Silva Júnior" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Gdayllon Cavalcante" "apellidos" => "Meneses" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "Alice Maria Costa" "apellidos" => "Martins" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 7 => array:4 [ "nombre" => "Elizabeth De Francesco" "apellidos" => "Daher" "email" => array:2 [ 0 => "ef.daher@uol.com.br" 1 => "geraldobezerrajr@unifor.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Medical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Public Health Post-Graduation Program, School of Medicine, Health Sciences Center, University of Fortaleza, Ceará, Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad renal asociada con esteroides anabólicos androgénicos y abuso de suplementos vitamínicos: ¡tenga cuidado!" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1353 "Ancho" => 2495 "Tamanyo" => 331463 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pathophysiology of kidney injury due to AAS use. AAS, anabolic androgenic steroids. Question marks indicate mechanisms that are not understood. AQP, aquaporin. PCT, proximal convoluted tubule. CD, collecting duct. MAP, mean arterial pressure. FSGS, focal segmental glomerulosclerosis. TNF-α, tumor necrosis factor α. ATN, acute tubular necrosis. AIN, acute interstitial nephritis. CIN, chronic interstitial nephritis. GN, glomerulonephropathy. uKIM-1, urinary kidney injury molecule 1. uMCP-1, urinary monocyte chemoattractant protein 1. uNGAL, urinary neutrophil gelatinase-associated lipocalin. uALP, urinary alkaline phosphatase. uγ-GT, urinary γ-glutamil transpeptidase. CKD, chronic kidney disease. AKI, acute kidney injury.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The excessive chase for beauty standards has contributed to the rise of a body image disorder, especially in the young male population: muscle dysmorphia, also known as bigorexia, which is characterized by an obsessive preoccupation that the own body is still insufficiently muscular.<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">1,2</span></a> It is associated with other psychiatric conditions, such as mood disorders and anxiety<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">1,3,4</span></a> and has ultimately led to an increase in androgenic–anabolic steroids (AAS) and intramuscular injections of oily compounds abuse.<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">1,5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Steroid abuse is not restricted to professional bodybuilders. In fact, amateurs represent the largest share of AAS users.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">6</span></a> A recent study estimated that 2.9–4.0 million North Americans aged from 13 to 50 years had already used AAS, 32.5% of which developed dependence.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">7</span></a> These statistics reveal AAS dependence as a public health issue, with figures comparable to those of HIV infection and type-1 diabetes mellitus.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">8</span></a> In a Brazilian systematic review, the prevalence of AAS abuse was 2.1–31.6% and the highest prevalence was found among physical education professors and students. This finding is extremely alarming, for these individuals often help and guide other people's physical activity.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Simultaneous use of multiple substances commonly impairs evaluation of adverse effects of each one in isolation.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">4</span></a> It is well known that AAS impacts several organ systems. Side effects vary from hypogonadism due to suppression of hypothalamus-pituitary-testis endocrine axis to cardiovascular disorders, including dyslipidemia, cardiomyopathies and arrhythmias.<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">8,10,11</span></a> On the other hand, the abuse of intramuscular oily compounds (generally vitamins for veterinary use) might result in infection at the site of application, deformities, ulcerations, necrosis, embolism, nerve lesion and formation of foreign body granulomas, which isolate the injected material.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">5</span></a> Both substances are also associated with renal damage.</p><p id="par0020" class="elsevierStylePara elsevierViewall">This review of literature discusses kidney injury associated with the use of AAS and intramuscular oily compounds, highlighting the mechanisms of renal lesion and future perspectives regarding evaluation and early diagnosis of kidney injury in these patients. It is important to note that the studies describing the adverse effects related to the use of such substances are still scarce, mostly due to ethical issues, poor understanding of the importance of this topic and patient's refusal to reveal their condition to physicians.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Kidney injury associated with intramuscular vitamin supplementation</span><p id="par0025" class="elsevierStylePara elsevierViewall">Veterinary medications for bovines and equines containing vitamins A, D and E in an oily vehicle (known as ADE) do not enhance muscle hypertrophy, but the substance itself occupies space in the muscle surface or in the subcutaneous tissue, which leads to a result that is only visually similar to hypertrophy.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">5</span></a> While doses of ADE for veterinary purposes are, in average, 5<span class="elsevierStyleHsp" style=""></span>mL every 120 days, in periods of fattening,<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">5</span></a> Libório et al.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">12</span></a> reported a patient who used monthly doses of 50<span class="elsevierStyleHsp" style=""></span>mL for 2 years.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Both acute kidney injury (AKI) and chronic kidney disease (CKD) have been reported.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">12–17</span></a> A series of 16 ADE users by Daher et al.,<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">18</span></a> revealed that 13 patients had AKI according to KDIGO,<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">19</span></a> 7 of which were stage III, 2 required dialysis, and one of them progressed to dialysis-dependent end-stage CKD. Other important findings were hypercalcemia (Ca<span class="elsevierStyleSup">2+</span> >10.5<span class="elsevierStyleHsp" style=""></span>mg/dL or 2.62<span class="elsevierStyleHsp" style=""></span>mmol/L) in 11 patients; high 25-hydroxivitamin D levels (>100<span class="elsevierStyleHsp" style=""></span>ng/mL) in 9; and suppressed serum levels of parathyroid hormone (PTH)<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>pg/mL in 6 (only 7 patients had their PTH assessed). Treatment consisted in controlling calcium levels and complications, mainly with vigorous crystalloid infusion, corticoids and loop diuretics. Following reversal of hypercalcemia, renal function tended to improve. The data are compatible with different reports in literature.<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">12–17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The 25-hydroxivitamin D contained in the intramuscular injections is probably not the only responsible for the clinical picture, since the latent interval between the beginning of ADE use and hospitalization due to the onset of symptoms was 28 months,<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">18</span></a> which is longer than expected. On the other hand, hypercalcemia also develops with cosmetic injections, like paraffin, silicone and polymethyl methacrylate.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">20</span></a> A possible common mechanism is the formation of granulomas, which express the 1-α-hydroxylase enzyme, which catalyzes the conversion of 25-hydroxivitamin <span class="elsevierStyleSmallCaps">D</span> into its active form 1.25-hydroxivitamin D.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">21</span></a> This mechanism is corroborated by the decrease in calcium levels with the administration of glucocorticoids, which are effective against hypercalcemia associated with granulomatous diseases.<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">22,23</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">However, a review by Tachamo et al.,<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">20</span></a> analyzing 23 silicone and polymethyl methacrylate users, revealed a mean latent interval of approximately 95 months, which is even longer than that of ADE users. In addition, Tachamo et al.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">20</span></a> found high 1,25-hydroxivitamin D with low or normal 25-hydroxivitamin D levels, while Daher et al.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">18</span></a> found high levels of both. Therefore, the absorption of the 25-hydroxivitamin D contained in the injections is probably significant and may accelerate the onset of symptoms.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Although rare, hypervitaminosis A secondary to the absorption of the injected vitamin may also contribute to hypercalcemia,<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">24</span></a> possibly by increasing bone reabsorption via vitamin A receptors in osteoclasts.<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">25–27</span></a> However, only one case report assessed vitamin A levels, which were on the upper limit of normality.<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">17</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Renal impairment secondary to hypercalcemia may happen through different mechanisms, such as reversible vasoconstriction due to calcium's direct effect on vascular smooth muscle, decreasing renal blood flow and leading to prerenal AKI.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">28</span></a> Acquired nephrogenic diabetes <span class="elsevierStyleItalic">insipidus</span> and polyuria are found in up to 20% of patients with persistent hypercalcemia and may also contribute to prerenal AKI. Pathophysiology is not completely elucidated, but impairment of the countercurrent mechanism and downregulation of aquaporins 2 and 3 may be involved.<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">29–32</span></a> It is important to consider that polyuria might represent an adaptive mechanism, for dilution of urinary calcium decreases chances of precipitation in renal tissue.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Chronic hypercalciuria originates Randall plaques, which are calcium-phosphate precipitates on the basement membrane of the thin descending limb of the loop of Henle. These plaques grow towards the tubular lumen or the interstitium, causing nephrolithiasis or nephrocalcinosis, respectively, by serving as anchored sites for calcium-oxalate adhesion.<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">33–36</span></a> These effects are responsible for the progression to CKD.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The mechanisms of hypercalcemia and their association with kidney injury in ADE users are illustrated in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Kidney damage due to the use of anabolic steroids</span><p id="par0065" class="elsevierStylePara elsevierViewall">Testosterone and its synthetic hormonal derivates are collectively called AAS, given their anabolic and androgenic effects. More studies are being performed in order to develop substances with predominant anabolic action.<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">8,37,38</span></a> Such substances would reduce adverse effects such as testicular atrophy, infertility, erectile dysfunction, gynecomastia and loss of libido.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">8</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In the United States, the most frequently used AAS by high performance athletes, are testosterone, stanozolol, nandrolone and boldenone.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">8</span></a> Among amateur bodybuilders, boldenone, nandrolone, trenbolone and testosterone are the most common.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">7</span></a> A study performed by Iriart et al.<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">39</span></a> in Northeast Brazil indicated testosterone and nandrolone as the most often used AAS.</p><p id="par0075" class="elsevierStylePara elsevierViewall">A six-year follow-up study by El-Reshaid et al.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">40</span></a> analyzes renal biopsies of 22 AAS and growth hormone (GH) users with high-protein dietary intake who were referred to the local nephrology unit due to altered renal function, hematuria and/or proteinuria. Focal segmental glomerulosclerosis (FSGS) was found in 8 patients, nephroangiosclerosis in 4; chronic interstitial nephritis (CIN) in 3; acute interstitial nephritis (AIN) in 2; nephrocalcinosis with CIN in 2; membranous glomerulopathy in 1; crescentic glomerulopathy in 1; and sclerosing glomerulonephritis in 1. All patients with nephrocalcinosis were hypercalcemic and reported high consumption of milk (in average, 10<span class="elsevierStyleHsp" style=""></span>l per day) instead of water, in order to increase protein intake. During the follow-up, it was observed that patients diagnosed with FSGS had longer exposure to AAS, later disease onset and worse prognosis. On the other hand, patients with interstitial disease, as CIN or AIN, had shorter exposure to AAS and earlier disease onset, with stabilization or improvement after withholding AAS.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">40</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Herlitz et al.<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">41</span></a> studied renal biopsies of 10 AAS users who presented proteinuria and renal failure. Nine patients were diagnosed with FSGS. Direct glomerular toxicity by AAS and glomerular hyperfiltration due to increased body mass (similarly to obesity) were proposed as mechanisms of injury. Doublier et al.<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">42</span></a> conducted experimental studies with female estrogen receptor knockout mice and also demonstrated the development of glomerulosclerosis. It was concluded that androgen and estrogen receptors in podocytes have opposite effects: the former induces damage and apoptosis while the latter has a protective effect.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Satoshi et al.<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">43</span></a> have performed an experiment with orchidectomized rats that suggested a testosterone-mediated increase in urinary leucine aminopeptidase (LAP), γ-glutamyl transpeptidase (γ-GT) and alkaline phosphatase (ALP), which are enzymes present on the brush border membrane (BBM). Although also present elsewhere in the human body, they are too large to undergo glomerular filtration, hence their presence in the urine indicates renal damage or their upregulation on the BBM. Urinary glucose, cystatin C and β2-microglobulin, which are reabsorbed by renal tubules, were also increased by testosterone.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Another experimental study by Patil et al.<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">44</span></a> with male rats found a protective effect of low-dose testosterone against ischemia-reperfusion injury. However, a higher dose increased TNF-α and intrarenal T cells, failing to elicit a protective effect. Therefore, TNF-α is possibly a key cytokine involved in AAS-associated renal damage. Loh et al.<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">45</span></a> demonstrated testosterone-mediated increased expression of aquaporins (AQPs)-1 and 7 in the proximal convoluted tubule (PCT) and AQPs-2,4 and 6 in the collecting duct (CD) and consequent elevation of mean arterial pressure (MAP) in rats. This finding suggests that AAS could increase water reabsorption, causing hypertension and chronic kidney disease.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Urological changes may also be involved in AAS renal damage. Shortliffe et al.<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">46</span></a> observed an increased bladder-to-body mass ratio and a lower collagen-to-smooth muscle ration in the bladder of rats treated with testosterone. Kidney-to-body mass ratio was also increased, although there was a lower glomerular density in the group treated with testosterone.</p><p id="par0100" class="elsevierStylePara elsevierViewall">In order to increase bioavailability and enable oral administration, 17-α-alkylation of AAS molecules has been performed. Stanozolol, one of the most frequently used AAS, is an example of a 17-α-alkylated androgen. However, these steroids are known to be hepatotoxic and cases of severe cholestasis associated with AKI have been reported.<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">47,48</span></a> Bile acid nephropathy is thought to be the pathophysiologic mechanism of renal impairment in these patients.<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">47</span></a> Besides hepatic tumors, such as adenoma, which is well associated with AAS, there are also isolated reports of Wilms tumor.<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">49</span></a> In addition, hypercalcemia and nephrocalcinosis in AAS users who had not received intramuscular oily solutions have also been reported.<a class="elsevierStyleCrossRefs" href="#bib0530"><span class="elsevierStyleSup">50,51</span></a> The underlying pathophysiology in these patients is still elusive.<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">52–54</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">An experimental study with rats conducted by Frankenfeld et al.<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">55</span></a> revealed disruption in redox homeostasis in the liver, heart and kidneys of animals treated with AAS. Chronic kidney disease in AAS users is usually asymptomatic for a long time before diagnosis. Moreover, given their increased muscle mass, creatinine levels are frequently elevated in this group of patients, even when renal damage is absent. Therefore, new strategies are needed for accurate and timely diagnosis, and novel biomarkers are currently being studied for that purpose. Daher et al.<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">56</span></a> conducted a recent study and demonstrated an increase in creatinine and monocyte chemoattractant protein-1 (MCP-1) levels among AAS users, suggesting subclinical renal inflammation. It was our group's first study to analyze the role of novel biomarkers in AAS-related kidney injury. The pathophysiology of renal damage due to AAS use is summarized in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0110" class="elsevierStylePara elsevierViewall">The inadvisable use of AAS and parenteral vitamins is a public health issue. Parenteral ADE is well associated with vitamin D overload and hypercalcemia, which probably derives from 1-α-hydroxylase-producing granulomas as well as absorption of the injected vitamin D. Hypercalcemia leads to nephrocalcinosis, nephrolithiasis and prerenal AKI. In AAS abuse, glomerular and interstitial damage occur by direct renal toxicity, glomerular hyperfiltration and hypercalcemia. Novel biomarkers for early diagnosis are currently being studied. High levels of MCP-1 were associated with AAS use. Larger studies are needed, since the majority of evidence is based on case and series reports. Finally, raising awareness of the risks and the great health burden of AAS and ADE abuse is probably the best strategy available at the moment for preventing complications.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Key points</span><p id="par0115" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0120" class="elsevierStylePara elsevierViewall">Steroid and vitamin supplements abuse is a public health problem that can cause kidney injury, including acute kidney injury and chronic kidney disease.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0125" class="elsevierStylePara elsevierViewall">The most frequent and severe complication associated with vitamin supplement abuse is related with extreme doses of vitamin D, which leads to hypercalcemia, calcifications and renal damage.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0130" class="elsevierStylePara elsevierViewall">Anabolic steroids use has been associated with glomerular abnormalities and proteinuria.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0135" class="elsevierStylePara elsevierViewall">Novel biomarkers could be important to early detect kidney injury associated with the use of these substances and prevent further injury.</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflict of interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1318545" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1216580" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1318544" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1216581" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Kidney injury associated with intramuscular vitamin supplementation" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Kidney damage due to the use of anabolic steroids" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Key points" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 10 => array:2 [ "identificador" => "xack454576" "titulo" => "Acknowledgements" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-05" "fechaAceptado" => "2019-06-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1216580" "palabras" => array:6 [ 0 => "Acute kidney injury" 1 => "Androgenic–anabolic steroids" 2 => "Chronic kidney disease" 3 => "Hypercalcemia" 4 => "Vitamin D" 5 => "Vitamin supplements" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1216581" "palabras" => array:6 [ 0 => "Lesión renal aguda" 1 => "Esteroides androgénicos-anabólicos" 2 => "Enfermedad renal crónica" 3 => "Hipercalcemia" 4 => "Vitamina D" 5 => "Suplementos vitamínicos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The excessive chase for beauty standards and the rise of muscle dysmorphia have ultimately led to an increase in androgenic–anabolic steroids (AAS) and intramuscular injections of vitamins A, D and E (ADE) abuse, which is associated with several adverse effects and has become a public health issue. This review of literature discusses kidney injury associated with the use of AAS and ADE, highlighting the mechanisms of acute and chronic renal lesion, such as direct renal toxicity, glomerular hyperfiltration and hypercalcemia. Future perspectives regarding evaluation and early diagnosis of kidney injury in these patients are also discussed.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La búsqueda excesiva de los estándares estéticos y el aumento de casos de dismorfia muscular han llevado a un aumento excesivo del consumo de esteroides anabólicos androgénicos (AAS, por sus siglas en inglés) e inyecciones intramusculares de vitaminas A, D y E (ADE), que se asocian con varios efectos adversos y se convierte en un problema de salud pública. Esta revisión de literatura analiza la lesión renal asociada con el uso de AAS y vitaminas ADE, destacando los mecanismos de la lesión renal aguda y crónica, como la toxicidad renal directa, la hiperfiltración glomerular y la hipercalcemia. También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes.</p></span>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Adapted from Daher et al.<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">19</span></a>" "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1358 "Ancho" => 2492 "Tamanyo" => 259313 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Possible mechanisms of hypercalcemia and kidney injury associated with the use of intramuscular vitamins A, D and E. ADE, intramuscular vitamins A, D and E. 25(OH)D3, 25-hydroxivitamin D. 1,25(OH)<span class="elsevierStyleInf">2</span>D3, 1, 25-hydroxivitamin D. sCa<span class="elsevierStyleSup">2+</span>, serum calcium. uCa<span class="elsevierStyleSup">2+</span>, urinary calcium. aNDI, acquired nephrogenic diabetes insipidus. CKD, chronic kidney injury. AKI, acute kidney injury.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1353 "Ancho" => 2495 "Tamanyo" => 331463 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pathophysiology of kidney injury due to AAS use. AAS, anabolic androgenic steroids. Question marks indicate mechanisms that are not understood. AQP, aquaporin. PCT, proximal convoluted tubule. CD, collecting duct. MAP, mean arterial pressure. FSGS, focal segmental glomerulosclerosis. TNF-α, tumor necrosis factor α. ATN, acute tubular necrosis. AIN, acute interstitial nephritis. CIN, chronic interstitial nephritis. GN, glomerulonephropathy. uKIM-1, urinary kidney injury molecule 1. uMCP-1, urinary monocyte chemoattractant protein 1. uNGAL, urinary neutrophil gelatinase-associated lipocalin. uALP, urinary alkaline phosphatase. uγ-GT, urinary γ-glutamil transpeptidase. CKD, chronic kidney disease. AKI, acute kidney injury.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:56 [ 0 => array:3 [ "identificador" => "bib0285" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body image disorders and abuse of anabolic–androgenic steroids among men" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.G. Pope" 1 => "J.H. Khalsa" 2 => "S. Bhasin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2016.17441" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2017" "volumen" => "317" "paginaInicial" => "23" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27930760" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0290" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013. p. 242–7." ] ] ] 2 => array:3 [ "identificador" => "bib0295" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symptom characteristics and psychiatric comorbidity among males with muscle dysmorphia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Cafri" 1 => "R. Olivardia" 2 => "J.K. Thompson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.comppsych.2008.01.003" "Revista" => array:6 [ "tituloSerie" => "Compr Psychiatry" "fecha" => "2008" "volumen" => "49" "paginaInicial" => "374" "paginaFinal" => "379" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18555058" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0300" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of anabolic androgenic steroids and polypharmacy: a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Dodge" 1 => "M.F. Hoagland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.drugalcdep.2010.11.011" "Revista" => array:6 [ "tituloSerie" => "Drug Alcohol Depend" "fecha" => "2011" "volumen" => "114" "paginaInicial" => "100" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21232881" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0305" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Doping cosmético: a problemática das aplicações intramusculares de óleos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V.C. Figueiredo" 1 => "P.R.P. Silva" 2 => "R.S. Trindade" 3 => "E.H. Rose" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Bras Med Esporte" "fecha" => "2011" "volumen" => "17" "paginaInicial" => "56" "paginaFinal" => "61" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0310" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Anabolic 500 survey: characteristics of male users versus nonusers of anabolic–androgenic steroids for strength training" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.J. Ip" 1 => "M.J. Barnett" 2 => "M.J. Tenerowicz" 3 => "P.J. Perry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1592/phco.31.8.757" "Revista" => array:7 [ "tituloSerie" => "Pharmacotherapy" "fecha" => "2011" "volumen" => "31" "paginaInicial" => "757" "paginaFinal" => "766" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21923602" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1040842818303688" "estado" => "S300" "issn" => "10408428" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0315" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The lifetime prevalence of anabolic–androgenic steroid use and dependence in Americans: current best estimates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.G. Pope Jr." 1 => "G. Kanayama" 2 => "A. Athey" 3 => "E. Ryan" 4 => "J.I. Hudson" 5 => "A. Baggish" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1521-0391.2013.12118.x" "Revista" => array:6 [ "tituloSerie" => "Am J Addict" "fecha" => "2014" "volumen" => "23" "paginaInicial" => "371" "paginaFinal" => "377" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24112239" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0320" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.G. Pope Jr." 1 => "R.I. Wood" 2 => "A. Rogol" 3 => "F. Nyberg" 4 => "L. Bowers" 5 => "S. Bhasin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/er.2013-1058" "Revista" => array:7 [ "tituloSerie" => "Endocr Rev" "fecha" => "2014" "volumen" => "35" "paginaInicial" => "341" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24423981" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028217304405" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0325" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of the use of anabolic–androgenic steroids in Brazil: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "O.S. Abrahin" 1 => "E.C. Sousa" 2 => "A.M. Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Subst Use Misuse" "fecha" => "2014" "volumen" => "49" "paginaInicial" => "1156" "paginaFinal" => "1162" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0330" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of doping agents, particularly anabolic steroids, in sports and society" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Sjoqvist" 1 => "M. Garle" 2 => "A. Rane" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(08)60801-6" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2008" "volumen" => "371" "paginaInicial" => "1872" "paginaFinal" => "1882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18514731" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002937815025880" "estado" => "S300" "issn" => "00029378" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0335" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Doping with anabolic androgenic steroids (AAS): adverse effects on non-reproductive organs and functions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Nieschlag" 1 => "E. Vorona" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11154-015-9320-5" "Revista" => array:6 [ "tituloSerie" => "Rev Endocr Metab Disord" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "199" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26373946" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0340" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The case: renal failure in a bodybuilder athlete diagnosis: nephrocalcinosis secondary to exogenous vitamin D intoxication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.B. Libório" 1 => "J.C. Nasserala" 2 => "A.S. Gondim" 3 => "E.F. Daher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2013.230" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2014" "volumen" => "85" "paginaInicial" => "1247" "paginaFinal" => "1248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24786891" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0345" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.F. Daher" 1 => "G.B. Silva Júnior" 2 => "A.L. Queiroz" 3 => "L.M. Ramos" 4 => "S.Q. Santos" 5 => "D.M. Barreto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int Urol Nephrol" "fecha" => "2009" "volumen" => "4" "paginaInicial" => "717" "paginaFinal" => "723" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0350" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia and acute kidney injury caused by abuse of a parenteral veterinary compound containing vitamins A, D, and E" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.N. Rocha" 1 => "C.S. Santos" 2 => "M.O. Avila" 3 => "C.L. Neves" 4 => "M. Bahiense-Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bras Nefrol" "fecha" => "2011" "volumen" => "33" "paginaInicial" => "467" "paginaFinal" => "471" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22189812" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0355" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute kidney injury associated with androgenic steroids and nutritional supplements in bodybuilders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.E. Almukhtar" 1 => "A.A. Abbas" 2 => "D.N. Muhealdeen" 3 => "M.D. Hughson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ckj/sfv032" "Revista" => array:6 [ "tituloSerie" => "Clin Kidney J" "fecha" => "2015" "volumen" => "8" "paginaInicial" => "415" "paginaFinal" => "419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26251708" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0360" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lots of steroids and vitamins, tons of complications. Hypercalcemia and nephrocalcinosis as important complications of performance-enhancing drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Bento" 1 => "P. Velho" 2 => "M. Carvalho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nefro.2015.09.005" "Revista" => array:6 [ "tituloSerie" => "Nefrología" "fecha" => "2015" "volumen" => "35" "paginaInicial" => "598" "paginaFinal" => "600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26474528" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0365" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hipercalcemia e insuficiência renal aguda após uso de suplemento veterinário" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.F. Ronsoni" 1 => "H.C. Santos" 2 => "B.S. Colombo" 3 => "C.G. Correa" 4 => "A.P.G. Moritz" 5 => "M.H.C. Coral" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5935/0101-2800.20170082" "Revista" => array:6 [ "tituloSerie" => "J Bras Nefrol" "fecha" => "2017" "volumen" => "39" "paginaInicial" => "467" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29319776" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0370" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute kidney injury due to excessive and prolonged intra-muscular injection of veterinary supplements containing vitamins A, D and E. A series of 16 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.F. Daher" 1 => "L.V.M. Martiniano" 2 => "L.L.L. Lima" 3 => "N.C.V. Leite Filho" 4 => "L.E.O. Souza" 5 => "P.H.D. Fernandes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nefro.2016.05.017" "Revista" => array:7 [ "tituloSerie" => "Nefrología" "fecha" => "2017" "volumen" => "37" "paginaInicial" => "61" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27577045" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S030228381101387X" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0375" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group KDIGO clinical practice guideline for acute kidney injury, Kidney Int Suppl. 2012;2:1–138." ] ] ] 19 => array:3 [ "identificador" => "bib0380" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia associated with cosmetic injections: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Tachamo" 1 => "A. Donato" 2 => "B. Timilsina" 3 => "S. Nazir" 4 => "S. Lohani" 5 => "R. Dhital" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1530/EJE-17-0938" "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "2018" "volumen" => "178" "paginaInicial" => "425" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29453201" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0385" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extrarenal expression of 25-hydroxyvitamin D (3)-1 alpha-hydroxylase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Zehnder" 1 => "R. Bland" 2 => "M.C. Williams" 3 => "R.W. McNinch" 4 => "A.J. Howie" 5 => "P.M. Stewart" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.86.2.7220" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2001" "volumen" => "86" "paginaInicial" => "888" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11158062" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0390" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia caused by iatrogenic hypervitaminosis A" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.H. Bhalla" 1 => "D.M. Ennis" 2 => "E.D. Ennis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Diet Assoc" "fecha" => "2005" "volumen" => "105" "paginaInicial" => "119" "paginaFinal" => "121" "itemHostRev" => array:3 [ "pii" => "S0015028203005685" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0395" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia in granulomatous disorders: a clinical review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "O.P. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "442" "paginaFinal" => "447" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0400" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia and skeletal effects in chronic hypervitaminosis A" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Frame" 1 => "C.E. Jackson" 2 => "W.A. Reynolds" 3 => "J.E. Umphrey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7326/0003-4819-80-1-44" "Revista" => array:7 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1974" "volumen" => "80" "paginaInicial" => "44" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4810349" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673604157280" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0405" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retinoic acid directly stimulates osteoclastic bone resorption and gene expression of cathepsin K/OC-2" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Saneshige" 1 => "H. Mano" 2 => "K. Tezuka" 3 => "S. Kakudo" 4 => "Y. Mori" 5 => "Y. Honda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1042/bj3090721" "Revista" => array:6 [ "tituloSerie" => "Biochem J" "fecha" => "1995" "volumen" => "309" "paginaInicial" => "721" "paginaFinal" => "724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7639684" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0410" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alpharadiographic and histological observations on the skeletal effects of hypervitaminoses A and D in the rat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.F. Belanger" 1 => "I. Clark" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ar.1091580408" "Revista" => array:6 [ "tituloSerie" => "Anat Rec" "fecha" => "1967" "volumen" => "158" "paginaInicial" => "443" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4228328" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0415" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system, and calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Levi" 1 => "M.A. Ellis" 2 => "T. Berl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Invest" "fecha" => "1983" "volumen" => "71" "paginaInicial" => "1624" "paginaFinal" => "1632" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0420" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypercalcemia of malignancy and new treatment options" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Sternlicht" 1 => "I.G. Glezerman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ther Clin Risk Manag" "fecha" => "2015" "volumen" => "11" "paginaInicial" => "1779" "paginaFinal" => "1788" "itemHostRev" => array:3 [ "pii" => "S0015028210024039" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0425" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aqp3, p-aqp2, and aqp2 expression is reduced in polyuric rats with hypercalcemia: Prevention by camp-pde inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Wang" 1 => "C. Li" 2 => "T.H. Kwon" 3 => "M.A. Knepper" 4 => "J. Frøkiaer" 5 => "S. Nielsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol Ren Physiol" "fecha" => "2002" "volumen" => "283" "paginaInicial" => "1313" "paginaFinal" => "1325" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0430" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Sands" 1 => "F.X. Flores" 2 => "A. Kato" 3 => "M.A. Baum" 4 => "E.M. Brown" 5 => "D.T. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Physiol" "fecha" => "1998" "volumen" => "274" "paginaInicial" => "978" "paginaFinal" => "985" "itemHostRev" => array:3 [ "pii" => "S001502821832243X" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0435" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.C. Hebert" 1 => "E.M. Brown" 2 => "H.W. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Exp Biol" "fecha" => "1997" "volumen" => "200" "paginaInicial" => "295" "paginaFinal" => "302" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0440" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Bustamante" 1 => "U. Hasler" 2 => "V. Leroy" 3 => "S. de Seigneux" 4 => "M. Dimitrov" 5 => "D. Mordasini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2007010092" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2008" "volumen" => "19" "paginaInicial" => "109" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18032798" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0445" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The origin and growth of renal calculi" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Randall" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000658-193706000-00014" "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1937" "volumen" => "105" "paginaInicial" => "1009" "paginaFinal" => "1027" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17856988" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0450" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Papillary pathology as precursor of primary renal calculus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Randall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1940" "volumen" => "44" "paginaInicial" => "580" "paginaFinal" => "589" "itemHostRev" => array:3 [ "pii" => "S0090825813010731" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0455" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.P. Evan" 1 => "J.E. Lingeman" 2 => "F.L. Coe" 3 => "J.H. Parks" 4 => "S.B. Bledsoe" 5 => "Y. Shao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI17038" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "2003" "volumen" => "111" "paginaInicial" => "607" "paginaFinal" => "616" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12618515" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0460" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nephrocalcinosis: molecular insights into calcium precipitation within the kidney" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Sayer" 1 => "G. Carr" 2 => "N.L. Simmons" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1042/CS20040048" "Revista" => array:6 [ "tituloSerie" => "Clin Sci" "fecha" => "2004" "volumen" => "106" "paginaInicial" => "549" "paginaFinal" => "561" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15027893" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0465" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective androgen receptor modulators (SARMs) as function promoting therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Bhasin" 1 => "R. Jasuja" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MCO.0b013e32832a3d79" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Clin Nutr Metab Care" "fecha" => "2009" "volumen" => "12" "paginaInicial" => "232" "paginaFinal" => "240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19357508" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0470" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of selective androgen receptor modulators (SARMs)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Narayanan" 1 => "C.C. Coss" 2 => "J.T. Dalton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mce.2017.06.013" "Revista" => array:6 [ "tituloSerie" => "Mol Cell Endocrinol" "fecha" => "2018" "volumen" => "465" "paginaInicial" => "134" "paginaFinal" => "142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28624515" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0475" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body-building, steroid use, and risk perception among young body-builders from a low-income neighbourhood in the city of Salvador, Bahia State, Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A.B. Iriart" 1 => "T.M. Andrade" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0102-311x2002000500031" "Revista" => array:6 [ "tituloSerie" => "Cad Saude Publica" "fecha" => "2002" "volumen" => "18" "paginaInicial" => "1379" "paginaFinal" => "1387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12244371" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0480" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complementary bodybuilding: a potential risk for permanent kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W. El-Reshaid" 1 => "K. El-Reshaid" 2 => "S. Al-Bader" 3 => "A. Ramadan" 4 => "J.P. Madda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/1319-2442.229269" "Revista" => array:6 [ "tituloSerie" => "Saudi J Kidney Dis Transpl" "fecha" => "2018" "volumen" => "29" "paginaInicial" => "326" "paginaFinal" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29657200" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0485" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of focal segmental glomerulosclerosis after anabolic steroid abuse" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.C. Herlitz" 1 => "G.S. Markowitz" 2 => "A.B. Farris" 3 => "J.A. Schwimmer" 4 => "M.B. Stokes" 5 => "C. Kunis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2009040450" "Revista" => array:7 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2010" "volumen" => "21" "paginaInicial" => "163" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19917783" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090825818308965" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0490" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Testosterone and 17beta-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Doublier" 1 => "E. Lupia" 2 => "P. Catanuto" 3 => "S. Periera-Simon" 4 => "X. Xia" 5 => "K. Korach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2010.398" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2011" "volumen" => "79" "paginaInicial" => "404" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20962747" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0495" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex differences in the excretion levels of traditional and novel urinary biomarkers of nephrotoxicity in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Tsuji" 1 => "M. Sugiura" 2 => "S. Tsutsumi" 3 => "H. Yamada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2131/jts.42.615" "Revista" => array:6 [ "tituloSerie" => "J Toxicol Sci" "fecha" => "2017" "volumen" => "42" "paginaInicial" => "615" "paginaFinal" => "627" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28904297" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0500" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-α ratio and attenuating T-cell infiltration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.N. Patil" 1 => "K. Wallace" 2 => "B.D. LaMarca" 3 => "M. Moulana" 4 => "A. Lopez-Ruiz" 5 => "A. Soljancic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol Renal Physiol" "fecha" => "2016" "volumen" => "311" "paginaInicial" => "F395" "paginaFinal" => "F403" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0505" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of gonadectomy and testosterone treatment on aquaporin expression in the kidney of normotensive and hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.Y. Loh" 1 => "N. Giribabu" 2 => "N. Salleh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Exp Biol Med" "fecha" => "2017" "volumen" => "242" "paginaInicial" => "1376" "paginaFinal" => "1386" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0510" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Testosterone changes bladder and kidney structure in juvenile male rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.M. Shortliffe" 1 => "Y. Ye" 2 => "B. Behr" 3 => "B. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2014.01.012" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2014" "volumen" => "191" "paginaInicial" => "1913" "paginaFinal" => "1919" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24518779" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0515" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bile acid nephropathy in a bodybuilder abusing an anabolic androgenic steroid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.L. Luciano" 1 => "E. Castano" 2 => "G. Moeckel" 3 => "M.A. Perazella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/j.ajkd.2014.05.010" "Revista" => array:7 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2014" "volumen" => "64" "paginaInicial" => "473" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24953892" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090825812001850" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0520" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe cholestasis and bile acid nephropathy from anabolic steroids successfully treated with plasmapheresis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Flores" 1 => "R. Nustas" 2 => "H.L. Nguyen" 3 => "R.S. Rahimi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.14309/crj.2016.24" "Revista" => array:7 [ "tituloSerie" => "ACG Case Rep J" "fecha" => "2016" "volumen" => "3" "paginaInicial" => "133" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26958570" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002937812008617" "estado" => "S300" "issn" => "00029378" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0525" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wilms tumor in an adult associated with androgen abuse" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Prat" 1 => "G.F. Gray" 2 => "P.D. Stolley" 3 => "J.W. Coleman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "1977" "volumen" => "237" "paginaInicial" => "2322" "paginaFinal" => "2323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/192920" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028216613870" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0530" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multi-organ damage induced by anabolic steroid supplements: a case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.A. Samaha" 1 => "W. Nasser-Eddine" 2 => "E. Shatila" 3 => "J.J. Haddad" 4 => "J. Wazne" 5 => "A.H. Eid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1752-1947-2-340" "Revista" => array:5 [ "tituloSerie" => "J Med Case Rep" "fecha" => "2008" "volumen" => "2" "paginaInicial" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18976461" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0535" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nephrocalcinosis associated with the use of anabolic steroid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.M. Luchi" 1 => "R.N. Ricarte" 2 => "L.F. Roitman" 3 => "R. Santos Oda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Bras Nefrol" "fecha" => "2015" "volumen" => "37" "paginaInicial" => "135" "paginaFinal" => "140" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0540" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Caution for anabolic androgenic steroid use: a case report of multiple organ dysfunction syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Unai" 1 => "J. Miessau" 2 => "P. Karbowski" 3 => "M. Baram" 4 => "N.C. Cavarocchi" 5 => "H. Hirose" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Respir Care" "fecha" => "2013" "volumen" => "58" "paginaInicial" => "159" "paginaFinal" => "163" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0545" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anabolic androgenic steroid induced necrotising myopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Hughes" 1 => "S. Ahmed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-009-1235-6" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2011" "volumen" => "31" "paginaInicial" => "915" "paginaFinal" => "917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19859711" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0550" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rhabdomyolysis of the deltoid muscle in a bodybuilder using anabolic–androgenic steroids: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U. Farkash" 1 => "N. Shabshin" 2 => "M. Pritsch Perry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4085/1062-6050-44.1.98" "Revista" => array:7 [ "tituloSerie" => "J Athl Train" "fecha" => "2009" "volumen" => "44" "paginaInicial" => "98" "paginaFinal" => "100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19180225" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028203001572" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0555" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The anabolic androgenic steroid nandrolone decanoate disrupts redox homeostasis in liver, heart and kidney of male Wistar rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.P. Frankenfeld" 1 => "L.P. Oliveira" 2 => "V.H. Ortenzi" 3 => "I.C. Rego-Monteiro" 4 => "E.A. Chaves" 5 => "A.C. Ferreira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0102699" "Revista" => array:6 [ "tituloSerie" => "PLOS ONE" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e102699" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25225984" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028299005488" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0560" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel kidney injury biomarkers among anabolic androgenic steroids users – evidence of subclinical kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.F. Daher" 1 => "P.H.P.D. Fernandes" 2 => "G.C. Meneses" 3 => "G.F. Bezerra" 4 => "L.S.L. Ferreira" 5 => "G.A. Viana" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Asian J Sports Med" "fecha" => "2018" "volumen" => "9" "paginaInicial" => "e65540" "itemHostRev" => array:3 [ "pii" => "S0090825885710025" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack454576" "titulo" => "Acknowledgements" "texto" => "<p id="par0145" class="elsevierStylePara elsevierViewall">We are very grateful for the technical support provided for the development of this revision. E.F. Daher, G.B. Silva Junior and A.M.C Martins are recipients of a grant from the <span class="elsevierStyleGrantSponsor" id="gs1">Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)</span> and <span class="elsevierStyleGrantSponsor" id="gs2">Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)</span>.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000004000000001/v1_202003180708/S2013251420300237/v1_202003180708/en/main.assets" "Apartado" => array:4 [ "identificador" => "35443" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Reviews" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000004000000001/v1_202003180708/S2013251420300237/v1_202003180708/en/main.pdf?idApp=UINPBA000064&text.app=https://www.revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420300237?idApp=UINPBA000064" ]
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| 2021 January | 26 | 30 | 56 |
| 2020 December | 54 | 28 | 82 |
| 2020 November | 40 | 20 | 60 |
| 2020 October | 36 | 34 | 70 |
| 2020 September | 39 | 14 | 53 |
| 2020 August | 26 | 20 | 46 |
| 2020 July | 36 | 15 | 51 |
| 2020 June | 29 | 28 | 57 |
| 2020 May | 79 | 50 | 129 |
| 2020 April | 106 | 41 | 147 |
| 2020 March | 36 | 20 | 56 |
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