Letter to the Editor
Development of C3 glomerulopathy in a patient with acquired partial lipodystrophy
Desarrollo de glomerulopatía C3 en paciente con lipodistrofia parcial adquirida
Elena Hernández García
, Elena Borrego García, Antonio Navas-Parejo Casado
Corresponding author
Servicio de Nefrología, Hospital Universitario San Cecilio, Granada, Spain
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This antibody may be associated with adipose tissue abnormalities, causing acquired partial lipodystrophy (APL),<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> which may appear before or after the onset of C3G.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 52-year-old man with a medical history of hypertension and APL of recent onset, being treated with enalapril 5 mg/24 h. He was referred to a nephrology clinic due to detection of albuminuria with levels that had been rising for years. The patient was asymptomatic. Physical examination revealed a lack of adipose tissue on the cheekbones, neck, upper limbs and trunk; normal blood pressure; and no oedema in the lower limbs. Given the differential diagnosis of APL, we ruled out causes associated with panniculitis, autoimmune diseases such as Barraquer-Simons syndrome, acquired generalised lipodystrophy (Lawrence syndrome), membranous and membranoproliferative glomerulonephritis (GN) (following kidney biopsy), drugs (cortisol, insulin), and viral infections such as HIV infection. Complementary tests showed that the patient had normal kidney function with creatinine 0.89 mg/dl, urea 38 mg/dl, sodium 139 mEq/l, potassium 4.2 mEq/l, total protein 6.7 mg/dl, total cholesterol 240 mg/dl, decreased C3 < 15 mg/dl and C4 28.1 mg/dl, and negative immunoglobulins, serum protein electrophoresis, serology (HIV, HCV, HBV) and autoimmunity (ANA, ANCA, APO, anti-PLA2R). Urine testing revealed microhaematuria, albuminuria 3.7 g/24 h and proteinuria up to 3.8 g/24 h. A kidney ultrasound showed kidneys of a normal shape and size with normal differentiation between the cortex and the medulla and no other findings. Antiproteinuric therapy was intensified, but the patient's proteinuria remained in the nephrotic range during the follow-up. A kidney biopsy revealed pathology findings of granular deposits in the membrane with spread to the mesangium, with a widespread and diffuse pattern and positivity for C3 (3+), C4d (2+) and fibrinogen (1+), with a more segmental pattern and intensity ± 1 for IgM and lambda light chains. IgG, IgA, C4, C1q and kappa light chains were negative. The histology diagnosis was C3G with a lesion pattern more similar to membranous GN than to mesangiocapillary GN.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Anti-C3Nef autoantibodies were detected in serum (IdiPAZ).</p><p id="par0020" class="elsevierStylePara elsevierViewall">Treatment was started with corticosteroids on a down-titration regimen and mycophenolate mofetil 1 g/12 h. At present, the patient has normal kidney function with slight improvement in his albuminuria and proteinuria, 2.5 g/24 h and 2.8 g/24 h, respectively.</p><p id="par0025" class="elsevierStylePara elsevierViewall">APL is a very uncommon disease characterised by a gradual loss of adipose tissue of the head, neck, trunk and upper limbs.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Up to 75-90% of patients have decreased levels of the component C3 of the alternative complement pathway linked to the presence of anti-C3Nef, for which more than 80% of patients test positive.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The most common form of presentation of APL associated with C3G is dense deposit disease,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> although in some cases the histology study shows a histology pattern similar to IgA GN.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> We believe that our case is interesting first due to the diagnosis of C3G with a histology pattern similar to membranous GN, this type of presentation has not been previously reported, and second due to the development of APL, probably subsequent to kidney involvement.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In C3G case cohorts, only a limited percentage of patients have APL.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> However, among patients with lipodystrophy, up to 25% may develop C3G in the medium to long term.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,7</span></a> In these cases, the common mechanism is dysregulation of complement system, although the possibility that other associated factors are involved have yet to be determined and cannot be ruled out.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In conclusion, C3G is a rare disease, and in the presence of signs such as lipodystrophy, a proper differential diagnosis and follow up of these patients is essential to prevent or promptly intervene should nephropathy develop, if not present already.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-06-04" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García EH, García EB, Casado AN-P. Desarrollo de glomerulopatía C3 en paciente con lipodistrofia parcial adquirida. Nefrologia. 2020;40:486–487.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C3 nephriticfactors: a changing landscape" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Levy Erez" 1 => "K.E. Meyers" 2 => "K.E. Sullivan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Allergy Clin Immunol." 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| 2023 February | 39 | 20 | 59 |
| 2023 January | 31 | 41 | 72 |
| 2022 December | 56 | 37 | 93 |
| 2022 November | 56 | 48 | 104 |
| 2022 October | 54 | 49 | 103 |
| 2022 September | 47 | 49 | 96 |
| 2022 August | 33 | 43 | 76 |
| 2022 July | 43 | 51 | 94 |
| 2022 June | 38 | 51 | 89 |
| 2022 May | 48 | 40 | 88 |
| 2022 April | 52 | 60 | 112 |
| 2022 March | 44 | 64 | 108 |
| 2022 February | 46 | 49 | 95 |
| 2022 January | 46 | 48 | 94 |
| 2021 December | 53 | 50 | 103 |
| 2021 November | 40 | 40 | 80 |
| 2021 October | 52 | 69 | 121 |
| 2021 September | 38 | 40 | 78 |
| 2021 August | 45 | 54 | 99 |
| 2021 July | 31 | 27 | 58 |
| 2021 June | 24 | 32 | 56 |
| 2021 May | 40 | 50 | 90 |
| 2021 April | 88 | 83 | 171 |
| 2021 March | 55 | 44 | 99 |
| 2021 February | 49 | 31 | 80 |
| 2021 January | 34 | 19 | 53 |
| 2020 December | 26 | 15 | 41 |
| 2020 November | 47 | 25 | 72 |
| 2020 October | 33 | 21 | 54 |
Show all
