TY - JOUR T1 - Serum cystatin C levels in preterm newborns in our setting: Correlation with serum creatinine and preterm pathologies JO - Nefrología (English Edition) T2 - AU - Bardallo Cruzado,Leonor AU - Pérez González,Elena AU - Martínez Martos,Zoraima AU - Bermudo Guitarte,Carmen AU - Granero Asencio,Mercedes AU - Luna Lagares,Salud AU - Marín Patón,Mariano AU - Polo Padilla,Juan SN - 20132514 M3 - 10.1016/j.nefroe.2015.06.003 DO - 10.1016/j.nefroe.2015.06.003 UR - https://www.revistanefrologia.com/en-serum-cystatin-c-levels-in-articulo-S201325141500022X AB - BackgroundCystatin C (CysC) is a renal function marker that is not as influenced as creatinine (Cr) by endogenous or exogenous agents, so it is proposed as a marker in preterm infants. ObjectivesTo determine serum CysC values in preterm infants during the first week of life, compared to Cr. To analyse alterations caused by prematurity diseases. MethodThe design involved a longitudinal, observational study of prospective cohorts.Groups were based on gestational age (GA): Group A (24–27 weeks), Group B (28–33 weeks), Group C (34–36 weeks). Blood samples were collected at birth, within 48–72h and after 7 days of life. StatisticsSPSS v.20 software was used. The statistical methods applied included chi-squared test and ANOVA. ResultsA total of 109 preterm infants were included in the study. CysC levels were 1.54mg/l (±0.28) at birth, 1.38mg/l (±0.36) within 48–72h of life, and 1.50mg/l (±0.31) after 7 days (p<0.05). Cr levels were 0.64mg/dl (±0.17) at birth, 0.64mg/dl (±0.28) within 48–72h, and 0.56mg/dl (±0.19) after 7 days (P<.05). CysC values were lower in hypotensive patients and in those with a respiratory disease (P<.05), and no alterations associated with other diseases were observed. There were no differences in Cr levels associated with any disease. Creatinine levels were higher in patients ≤1.500g (P<.05). ConclusionsSerum CysC decreased within 48–72h of life, and this decline showed significance (P<.05). The levels increased after 7 days in all 3 GA groups, and there was no difference in CysC levels among the groups. More studies in preterm infants with hypotension and respiratory disease are required. CysC is a better glomerular filtration rate (GFR) marker in ≤1.500g preterm infants. ER -