TY - JOUR T1 - Calciphylaxis: Beyond CKD-MBD JO - Nefrología (English Edition) T2 - AU - Fernández,María AU - Morales,Enrique AU - Gutierrez,Eduardo AU - Polanco,Natalia AU - Hernández,Eduardo AU - Mérida,Eva AU - Praga,Manuel SN - 20132514 M3 - 10.1016/j.nefroe.2017.09.003 DO - 10.1016/j.nefroe.2017.09.003 UR - https://www.revistanefrologia.com/en-calciphylaxis-beyond-ckd-mbd-articulo-S201325141730158X AB - IntroductionCalcific uraemic arteriolopathy (CUA), also called calciphylaxis, is a rare but potentially fatal vascular disorder that almost exclusively affects patients with chronic renal failure. The objective of this study was to analyse various risk factors for developing CUA and its subsequent clinical course according to the treatment received. Materials and methodsA retrospective study that included patients diagnosed with CUA from December 1999 to December 2015. Various risk factors, clinical course and treatment options were analysed. ResultsA total of 28 patients (53.6% females) with a mean age of 67.2±11.8 (38–88) years were included. At the time of diagnosis, 53.6% were on haemodialysis, 25% were kidney transplant patients and 21.4% had normal renal function. The use of steroids (100%, p=0.001) was the main risk factor in renal transplant patients. Skin lesions resolved in 60.7% (especially in those receiving multitargeted therapy). Patient survival at 12 months was 29% in transplant patients, 57% in haemodialysis patients and 100% in normal renal function patients (log-rank 6.88, p=0.032). Chronic renal failure (p=0.03) and hypoalbuminaemia (p=0.02) were the main risk factor for CUA mortality. ConclusionsAlthough the incidence of CUA remains low, CUA mortality is very high, Special attention to its occurrence in kidney transplant patients and “non-renal” CUA forms is required. Oral anticoagulants and steroids appear to be the main risk factors, CUA is a challenge; a registry of patients and determining standard therapy are required. ER -