TY - JOUR T1 - Prospective evaluation of the development of contrast-induced nephropathy in patients with acute coronary syndrome undergoing rotational coronary angiography vs. conventional coronary angiography: CINERAMA study JO - Nefrología (English Edition) T2 - AU - Fernández-Rodríguez,Diego AU - Grillo-Pérez,José J. AU - Pérez-Hernández,Horacio AU - Rodríguez-Esteban,Marcos AU - Pimienta,Raquel AU - Acosta-Materán,Carlos AU - Rodríguez,Sara AU - Yanes-Bowden,Geoffrey AU - Vargas-Torres,Manuel J. AU - Sánchez-Grande Flecha,Alejandro AU - Hernández-Afonso,Julio AU - Bosa-Ojeda,Francisco SN - 20132514 M3 - 10.1016/j.nefroe.2018.02.001 DO - 10.1016/j.nefroe.2018.02.001 UR - https://www.revistanefrologia.com/en-prospective-evaluation-development-contrast-induced-nephropathy-articulo-S2013251418300245 AB - Introduction and objectivesRotational coronary angiography (RCA) requires less contrast to be administered and can prevent the onset of contrast-induced nephropathy (CIN) during invasive coronary procedures. The aim of the study is to evaluate the impact of RCA on CIN (increase in serum creatinine ≥0.5mg/dL or ≥25%) after an acute coronary syndrome. MethodsFrom April to September 2016, patients suffering acute coronary syndromes who underwent diagnostic coronary angiography, with the possibility of ad hoc coronary angioplasty, were prospectively enrolled. At the operator's discretion, patients underwent RCA or conventional coronary angiography (CCA). CIN (primary endpoint), as well as analytical, angiographic and clinical endpoints, were compared between groups. ResultsOf the 235 patients enrolled, 116 patients received RCA and 119 patients received CCA. The RCA group was composed of older patients (64.0±11.8 years vs. 59.7±12.1 years; p=0.006), a higher proportion of women (44.8 vs. 17.6%; p<0.001), patients with a lower estimated glomerular filtration rate (76±25 vs. 86±27ml/min/1.73m2; p=0.001), and patients who underwent fewer coronary angioplasties (p<0.001) compared with the CCA group. Furthermore, the RCA group, received less contrast (113±92 vs. 169±103ml; p<0.001), including in diagnostic procedures (54±24 vs. 85±56ml; p<0.001) and diagnostic-therapeutic procedures (174±64 vs. 205±98ml; p=0.049) compared with the CCA group. The RCA group presented less CIN (4.3 vs. 22.7%; p<0.001) compared to the CCA group, and this finding was maintained in the regression analysis (Adjusted relative risk: 0.868; 95% CI: 0.794–0.949; p=0.002). There were no differences in clinical endpoints between the groups. ConclusionsRCA was associated with lower administration of contrast during invasive coronary procedures in acute coronary syndrome patients, resulting in lower incidence of CIN, in comparison with CCA. ER -