TY - JOUR T1 - Factors associated with the compensation of renal function after nephrectomy of a kidney donor JO - Nefrología (English Edition) T2 - AU - Burballa,Carla AU - Crespo,Marta AU - Redondo-Pachón,Dolores AU - Pérez-Sáez,María José AU - Arias-Cabrales,Carlos AU - Mir,Marisa AU - Francés,Albert AU - Fumadó,Lluís AU - Cecchini,Lluís AU - Pascual,Julio SN - 20132514 M3 - 10.1016/j.nefroe.2018.10.002 DO - 10.1016/j.nefroe.2018.10.002 UR - https://www.revistanefrologia.com/en-factors-associated-with-compensation-renal-articulo-S2013251418301093 AB - IntroductionKidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood. MethodsRetrospective study of 66 consecutive kidney donors (mean age 48.8 years, 74.2% women). We analyzed the potential factors associated with the compensatory mechanisms of the remaining kidney by comparing donors according to their renal compensation rate (RCR) (Group A, infra-compensation [<70%]; Group B, normal compensation [>70%]). ResultsWe compared Group A (n=38) and group B (n=28). Predictors for RCR>70% were higher baseline creatinine (A vs. B: 0.73±0.14 vs. 0.82±0.11; p=0.03) and a lower baseline glomerular filtration rate (GFR), estimated both by MDRD-4 (A vs. B: 97.7±18.8 vs. 78.6±9.6ml/min; p<0.001) and CKD-EPI (A vs. B: 101.7±15 vs. 88.3±11.7ml/min; p≤0.001). Age, gender, smoking, hypertension and GFR measured by Tc-DTPA did not show any correlation with the RCR. The multivariate analysis confirmed baseline estimated glomerular filtration rate (eGFR) to be a predictor of compensation: the higher the baseline eGFR, the lower the likelihood of >70% compensation (MDRD-4, OR=0.94 [95% CI 0.8–0.9], p=0.01). The compensation rate decreased by 0.4% (p<0.001) and 0.3% (p=0.006) for every ml/min increase in baseline eGFR estimated by MDRD-4 and CKD-EPI, respectively. ConclusionsOne year after living donor nephrectomy, the remaining kidney partially compensates baseline renal function. In our experience, baseline eGFR is inversely proportional to the one-year renal compensation rate. ER -