TY - JOUR T1 - Review of alterations in gene expression and apoptotic pathways caused in nephrotoxicity induced by cisplatin JO - NefrologĂ­a (English Edition) T2 - AU - Bernal-Barquero,Carlos Eduardo AU - Vazquez-Zapien,Gustavo Jesus AU - Mata-Miranda,Monica Maribel SN - 20132514 M3 - 10.1016/j.nefroe.2018.11.019 DO - 10.1016/j.nefroe.2018.11.019 UR - https://www.revistanefrologia.com/en-review-alterations-in-gene-expression-articulo-S2013251419301221 AB - Cisplatin (cis-diaminodichloroplatin (II), CDDP) is an antineoplastic drug used in the treatment of many types of cancer of solid organs. Although CDDP side effects include ototoxicity, gastric toxicity, myelosuppression and allergic reactions, the main limitation of this antineoplastic agent is nephrotoxicity, provoking acute kidney failure (AKI). The pathophysiology of AKI induced by CDDP is complex, there are several mechanisms involved, including nuclear and mitochondrial damage, activation of apoptosis signaling pathways, generation of reactive oxygen species, and inflammation. In this review, we describe the molecular events of CDDP, which cause nephrotoxicity, affecting the expression of several genes involved in metabolism and activating different apoptotic signaling pathways, highlighting the main cellular targets of this antineoplastic and the approach of possible treatments for AKI caused by CDDP. ER -