TY - JOUR T1 - Envarsus, a novelty for transplant nephrologists: Observational retrospective study JO - Nefrología (English Edition) T2 - AU - Franco,Antonio AU - Más-Serrano,Patricio AU - Balibrea,Noelia AU - Rodriguez,David AU - Javaloyes,Aurora AU - Díaz,Marcos AU - Gascón,Isabel AU - Ramon-Lopez,Amelia AU - Perez-Contreras,Javier AU - Selva,Juan AU - Nalda-Molina,Ricardo SN - 20132514 M3 - 10.1016/j.nefroe.2018.11.020 DO - 10.1016/j.nefroe.2018.11.020 UR - https://www.revistanefrologia.com/en-envarsus-novelty-for-transplant-nephrologists-articulo-S2013251419301397 AB - The aim of this study was to evaluate the trough concentrations (Cptrough) and the tacrolimus dosage regimen after the conversion of Prograf or Advagraf to Envarsus (new pharmaceutical form with MeltDose technology that improves the absorption of fat-soluble drugs) in patients with stable renal transplantation, and their renal function.We selected stable renal transplant patients who were converted to Envarsus. Two periods were defined: Baseline and Conversion (Envarsus) and they were stratified according to the pharmaceutical form used in the Baseline period. Sixty-one patients were included (24 with Advagraf and 37 with Prograf), with an average age of 52years. The mean post-transplant time at the time of conversion to Envarsus was 76.3months and the mean follow-up in the Baseline and Conversion period was 10.1months and 11.6months, respectively.In the Prograf and Envarsus group, the Cptrough medians were 6.6 vs 6.4ng/ml (p=.636), with a mean daily dose that decreased significantly from 3mg to 2mg (p<.001), respectively, maintaining the filtration rate.The median Cptrough values in the Advagraf and Envarsus groups were 5.7ng/ml and 6.3ng/ml (p=.07), with a median daily dose of 7mg and 4mg (p<.001), respectively, and the same renal function.In stable renal transplant patients, the conversion from Advagraf to Envarsus has allowed the dose of tacrolimus to be reduced by 42.9% and, in the case of Prograf, by 33.3%, maintaining similar Cptrough values, without renal function being altered. ER -