TY - JOUR T1 - Extended hemoperfusion in the treatment of acute carbamazepine intoxication JO - Nefrología (English Edition) T2 - AU - Peces Serrano,Ramón AU - Azorín,S. AU - Peces,C. AU - Selgas,R. SN - 20132514 M3 - 10.3265/Nefrologia.pre2010.Jan.10217 DO - 10.3265/Nefrologia.pre2010.Jan.10217 UR - https://www.revistanefrologia.com/en-extended-hemoperfusion-in-treatment-acute-articulo-X2013251410033933 AB - Carbamazepine is used in the treatment of epilepsy, and also prescribed in neuralgic pain syndromes, and certain affective disorders. Carbamazepine intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, arrhythmia, hemodynamic instability and death. The drug's relatively high molecular weight, elevated volume of distribution and intense protein-binding render it difficult to extracorporeal removal, but published experience with hemoperfusion or hemodialysis present variable results. We describe a case report involving carbamazepine intoxication who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of carbamazepine was reduced with rapid lowering of carbamazepine levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, extended charcoal hemoperfusion should be considered for serious carbamazepine intoxication because free as well as bound drug fractions are eliminated via this technique. ER -