TY - JOUR T1 - Factors related with the progression of chronic kidney disease JO - Nefrología (English Edition) T2 - AU - Yuste,Claudia AU - Barraca,Daniel AU - Aragoncillo-Sauco,Inés AU - Aragoncillo Sauco,ines AU - Vega-Martínez,Almudena AU - Vega Martínez,Almudena AU - Abad,Soraya AU - Verdalles-Guzmán,Úrsula AU - Verdalles Guzmán,Ursula AU - Ruiz-Caro,Caridad AU - Ampuero,Jara AU - López-Gómez,Juan M. AU - López-Gómez,Juan Manuel SN - 20132514 M3 - 10.3265/Nefrologia.pre2013.May.11900 DO - 10.3265/Nefrologia.pre2013.May.11900 UR - https://www.revistanefrologia.com/en-factors-related-with-progression-chronic-articulo-X2013251413053120 AB - Background: Our aims were to determine the rate of progression of chronic kidney disease (CKD) and to identify predictors, with particular emphasis on bone and mineral metabolism. Methods: Retrospective and observational study including 300 patients with advanced CKD (61.2% males, 33.1% diabetics; age 65.6±14 years). Mean follow-up time was19.4±10.1 months. Baseline estimated glomerular filtration rate (eGFR) (MDRD-4) was 22.5±7.18mL/min. To calculate the rate of decline in eGFR, we used the slope of the regression line between all determinations of eGFR and follow-up time. We calculated the mean values for proteinuria and serum phosphate, calcium, uric acid, and PTH, as well as 24-hour urinary excretion of urea nitrogen over time for each patient. Follow-up was at least 6 months and included at least 4 measurements of eGFR. Results: The mean rate of decline eGFR (–1.64 mL/min/1.73m2/year) was inversely correlated with serum phosphate levels (4.3±2.1 mg/dL, p<.001), PTH (256.3±193.7ng/L, p<.001) and proteinuria (0.84±1.31g/day, p=.004) and directly correlated with mean serum calcium (p<.001) and the presence of hypertension (p<.02). However, only serum phosphate, serum PTH, and proteinuria persisted as predictors in the multivariate analysis. Stable-GFR patients (positive slope) were older (p=.041) and had lower serum phosphate and PTH levels (p<.01 and p<.01 respectively) and lower proteinuria (p<.01). Conclusions: The rate of decrease in eGFR was correlated with serum phosphate and PTH levels and proteinuria. All of these factors can be modified with an adequate treatment. ER -