TY - JOUR T1 - Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: Results from the VACH longitudinal cohort study JO - Nefrología T2 - AU - Domingo,Pere AU - Suarez-Lozano,Ignacio AU - Gutierrez,Félix AU - Estrada,Vicente AU - Knobel,Hernando AU - Palacios,Rosario AU - Antela,Antonio AU - Blanco,José-Ramón AU - Fulladosa,Xavier SN - 02116995 M3 - 10.1016/j.nefro.2019.01.009 DO - 10.1016/j.nefro.2019.01.009 UR - https://www.revistanefrologia.com/es-predictive-factors-renal-impairment-in-articulo-S0211699519300566 AB - BackgroundThe use of combination antiretroviral therapy has led to dramatic improvements in the life expectancy of HIV-infected persons. As result, the HIV population is aging and increasingly facing illnesses typically seen in the elderly, such as chronic kidney disease (CKD). MethodsA retrospective longitudinal study was conducted using data from years 2010 and 2014 in all HIV-infected persons enrolled at the Spanish VACH cohort. We analyzed the prevalence and the predictive factors for developing CKD (estimated glomerular filtration rate, eGFR<60mL/min/1.73m2). ResultsThe CKD prevalence at baseline was 456/8968, 5.1% [4.6–5.6%]. Of 8512 HIV-positive individuals examined without CKD at baseline (73.7% male, median age 44 years-old), 2.15% developed CKD (eGFR<60mL/min/1.73m2). The odds ratios [95%CI] for the independent predictive factors identified were gender (male) 0.54 [0.39–0.75], age (per year) 1.08 [1.07–1.10], AIDS diagnosis 1.40 [1.03–1.91], protease inhibitor-based regimens 1.49 [1.10–2.02], hypertension 1.37 [0.94–1.99], diabetes 1.84 [1.33–2.55] and history of cardiovascular events 1.66 [0.96–2.86]. ConclusionThe prevalence and risk factors for CKD and its progression are high in the VACH cohort. Thus, preventive measures such as control of hypertension, diabetes and obesity, as well as efforts for avoiding exposure to nephrotoxic drugs, including some antiretrovirals, are warranted in this aging HIV population. ER -