Trends in Cell Biology
Volume 1, Issues 2–3, August–September 1991, Pages 39-42
ForumA role for oxygen radicals as second messengers
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2018, Archives of Biochemistry and BiophysicsCitation Excerpt :TNF-α and IL-1α promote the formation of reactive oxygen species (ROS), which in turn activate the transcription factor nuclear factor (NF)-κB [2] and induce the translocation of NF-κB from the cytosol to the nucleus. H2O2 rapidly and effectively activates NF-κB signaling, and prolonged activation of NF-κB leads to the development of oxidative stress [3–6]. Oxidative stress occurs via increased production of reactive oxygen species (ROS) or impairment of antioxidant defenses that neutralize ROS [7].
Copyright © 1991 Published by Elsevier Ltd.