Meeting paperPCOGS papersIntraabdominal fat, insulin sensitivity, and cardiovascular risk factors in postpartum women with a history of preeclampsia
Section snippets
Study design
This was a cross-sectional study comparing body fat distribution, insulin sensitivity, β-cell function, fasting lipids, hepatic lipase activity, and endothelial function between postpartum women who had either an uncomplicated pregnancy (control group) or a history of preeclampsia (prior preeclampsia group). The study was approved by the University of Washington Institutional Review Board prior to initiation. All subjects provided written informed consent to participate.
Subjects
Subjects were recruited
Results
There were no differences between the groups in the matching variables, frequencies of exercise, or first-degree relatives with type 2 diabetes mellitus, obesity, hypertension, and cardiovascular disease (Table 1). The majority (65.3%) of the women in the prior preeclampsia group had severe features; 46.9% delivered <36 weeks’ gestation.
In contrast to our hypothesis, women with prior preeclampsia did not have greater adiposity as compared to the controls (Table 2). In linear regression models
Comment
In our study of healthy postpartum women who were matched for BMI, women with prior preeclampsia had higher blood pressures, an atherogenic lipoprotein phenotype, and endothelial dysfunction compared to women who had uncomplicated pregnancies. We anticipated that women with prior preeclampsia would also have greater visceral adiposity and be insulin resistant. Only women with nonsevere preeclampsia had increased visceral adiposity and decreased insulin sensitivity. Moreover, it was their
Acknowledgments
We thank the participants for their contributions to the research and the nursing staff of the General Clinical Research Center at the University of Washington for their care of the participants. We would like to acknowledge Dr Steven E. Kahn for being the primary mentor for the first author, Dr Darcy R. Barry. We are thoroughly grateful for his enthusiastic commitment to this work, his encouragement as a mentor, and his contributions as an expert in the area of glucose metabolism and the role
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This work was supported by National Institutes of Health grant number K23 RR-016066 from the National Center for Research Resources, National Institutes of Health grant number K30 RR022293, a grant from GlaxoSmithKline (project number 49653-198), Clinical Nutrition Research Unit (DK-035816), Diabetes Research Center (DK-017047), and General Clinical Research Center (RR-000037) at the University of Washington, and the Medical Research Service of the Department of Veterans Affairs.
The authors report no conflict of interest.
Cite this article as: Barry DR, Utzschneider KM, Tong J, et al. Intraabdominal fat, insulin sensitivity, and cardiovascular risk factors in postpartum women with a history of preeclampsia. Am J Obstet Gynecol 2015;213:104.e1-11.