Original ResearchObstetricsEffect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life
Section snippets
Study population
All women were recruited from obstetrical databases of 2 tertiary medical centers in the Netherlands, all giving birth between 1998 and 2005. Medical records of women with a history of early-onset preeclampsia were screened consecutively, and all eligible women were invited. Participating women with a history of early-onset preeclampsia were matched with women with an uncomplicated pregnancy, for maternal age (range ± 5 years) and date of delivery (range ± 1 year). Early-onset preeclampsia was
Results
The baseline characteristics at index pregnancy are described in Table 1. Women with a history of early-onset preeclampsia were younger at delivery (P = .046), more often were primiparous (P = .001), and more often delivered via caesarean delivery (P < .0001) compared with women with an uncomplicated pregnancy history. As expected, the women with former early-onset preeclampsia had greater blood pressures during pregnancy (P < .0001). In addition, they had a shorter gestational age (P < .0001),
Comment
Women with a history of early-onset preeclampsia who were in the fifth decade of life had high rates of cardiovascular risk factors, although cardiovascular diseases had not developed yet. As a result, the women could still benefit from measures preventing cardiovascular disease. We conclude that there is a window of opportunity for preventive measures in women in their forties, for those who have a history of early-onset preeclampsia (42%).
We have found that 38.2% of women with early-onset
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The authors report no conflict of interest.
This research was funded, in part, by a grant from the Dutch Heart Association.
Cite this article as: Bokslag A, Teunissen PW, Franssen C, et al. Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life. Am J Obstet Gynecol 2017;216:523.e1-7.