Coronary artery diseasePrognostic Value of Neutrophil to Lymphocyte Ratio in Patients Presenting With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Section snippets
Methods
From July 2003 through February 2010, a total of 325 patients with STEMIs treated with primary PCI and with leukocyte profiles at admission and 24 hours thereafter were analyzed. We excluded patients with symptom onset >12 hours, underlying cancer, chronic inflammatory disease, or any systemic infection that occurred during the first 24 hours after admission. Patients referred to bypass surgery <24 hours after admission were excluded as well. Primary PCI was performed using conventional
Results
A total of 325 patients were available for the final analysis. The clinical and angiographic characteristics of the study population are listed in Table 1. Overall, the mean age was 60.9 years, and most patients were men (71%). Fifty percent of patients had hypertension, 27.4% had diabetes mellitus, and 35.7% had chronic kidney disease.
We examined whether there was a change in total and differential leukocyte counts between the initial measurement and those at 24 hours after admission. During
Discussion
In patients with STEMI who undergo primary PCI, we found a change in leukocyte profile during the first 24 hours after hospital admission, and the leukocyte profile at 24 hours after admission was correlated with clinical outcomes. Among leukocyte profiles, the 24-hour NLR best predicted mortality; patients with 24-hour NLRs ≥5.44 had 3.12-fold increased risk for death.
There are few reports of an association between baseline leukocyte profile in patients with acute myocardial infarctions and
Disclosures
The authors have no conflicts of interest to disclose.
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