Clinical-alimentary tractA Comparison of the Immunochemical Fecal Occult Blood Test and Total Colonoscopy in the Asymptomatic Population
Section snippets
Study Design
A committee at Kameda General Hospital approved this study protocol consisting of a retrospective analysis of an existing dataset from patients who participated in a comprehensive health examination program at Kameda General Hospital or Kameda Makuhari Clinic between April 1983 and March 2002. All patients completed a questionnaire designed to examine whether they had any symptoms and what kinds of symptoms they had. Patients were excluded if they reported symptoms of disease of the lower
Patients
Of the 22,666 participants enrolled in this study, a complete colonoscopy was performed in 22,259 patients (98.2%), and 407 patients were excluded because of an incomplete colonoscopy. There were no serious complications during or after the colonoscopy. Patients lacking sufficient information on the polypoid lesion (location, size, or pathologic findings) also were excluded (n = 454). In the end, we analyzed 21,805 patients, comprising 15,694 men and 6111 women, with a mean age of 48.2 ± 9.3
Discussion
We evaluated the sensitivity of Magstream 1000/Hem SP, a type of immunochemical FOBT, in asymptomatic participants who underwent a complete colonoscopy. Many studies have provided information on immunochemical FOBT sensitivity and specificity for the detection of CRC, in which the sensitivity ranged from 47.1% to 100%, and the specificity ranged from 88.2% to 97.1%. 4, 5, 19, 20, 21, 22, 23, 24, 25 In these studies, however, colonoscopy was performed only in FOBT-positive cases, 5, 6 or studies
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