Original InvestigationLong-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia
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Amgen (Thousand Oaks, California) provided funding for the study, and was responsible for the design and conduct of the study; conducted collection and management of data; participated in the analysis and interpretation of the data in partnership with independent authors; and participated in the preparation, review, or approval of the manuscript in partnership with the independent authors. Dr. Koren is employed by Jacksonville Center for Clinical Research, a company that has received research funds and consulting fees from Amgen, Pfizer, Regeneron, Sanofi, and The Medicines Company. Dr. Sabatine has received institutional research grant support from Abbott Laboratories, Amgen, AstraZeneca, Bayer, Daiichi-Sankyo, Eisai, Gilead, GlaxoSmithKline, Intarcia, Janssen Research and Development, The Medicines Company, MedImmune, Merck, Novartis, Poxel, Pfizer, Quark Pharmaceuticals, Roche Diagnostics, and Takeda; and has received consulting fees from Alnylam, Amgen, AstraZeneca, Bristol-Myers Squibb, CVS Caremark, DalCor, Dyrnamix, Esperion, IFM Therapeutics, Intarcia, Ionis, Janssen Research and Development, The Medicines Company, MedImmune, Merck, MyoKardia, and Novartis. Dr. Giugliano has received research grant support from Amgen; has received honoraria from Amgen, Amarin, Daiichi-Sankyo, Akcea, Bristol-Myers Squibb, CVS Caremark, and Pfizer. Dr. Langslet has received lecture and Advisory Board fees from Amgen, Sanofi, and Boehringer Ingelheim. Dr. Wiviott has received institutional grants from Amgen, Arena, AstraZeneca, Bristol-Myers Squibb, Daiichi-Sankyo, Eisai, Eli Lilly, Janssen, Merck, and Sanofi; has received consulting fees from Angel Medical Systems, ARENA, AstraZeneca, Allergan, Boehringer Ingelheim, Boston Clinical Research Institute, Bristol-Myers Squibb, Daiichi-Sankyo, Eisai, Eli Lilly, ICON Clinical Research, Janssen, Lexicon, Merck, St. Jude Medical, Servier, and Xoma; and his spouse is an employee of Merck. Drs. Ruzza and Hamer are employees of and own stocks/stock options in Amgen. Dr. Ma is employed as a contractor on behalf of Amgen. Dr. Wasserman is an employee of and holds stocks/stock options in Amgen; and appears on a number of pending patents owned by Amgen relating to evolocumab and PCSK9 inhibition. Dr. Raal has received research grants, honoraria, or consulting fees for professional input and/or delivered lectures from Sanofi, Regeneron, Amgen, and The Medicines Company.