Pancreas transplantation: whole glandSimultaneous pancreas-kidney transplantation: short- and long-term results
Section snippets
Methods
All SKPT patients transplanted between June 1985 and March 2003 were evaluated for inclusion in this study. The patient characteristics are depicted in Table 1. Overall, the duct occlusion technique with segmental pancreas was employed in 37 cases; bladder diversion in 73; and enteric diversion in 64 patients. Pancreas procurement utilized standard technique. In the segmental pancreas category, the body and the tail of the gland were removed from the donor and neoprene was injected according to
Results
The causes of graft failure are depicted in Table 2. Patients, pancreas, and kidney median survival times were 144, 131, and 144 months, respectively. In the segmental pancreas group, patient survival was 85%, 76%, and 53%, pancreas survival 67%, 36%, and 15%, and kidney survival 82%, 63%, and 15%, respectively, at 1, 5, and 10 years. In the bladder diversion group, patient survival was 94%, 83%, and 73% pancreas survival 72%, 67%, and 65%, and kidney survival 89%, 78%, and 58%, respectively,
Discussion
Patients with diabetes mellitus with renal failure have a high mortality on dialysis therapy. In our study, short- and long-term survival patient and graft survival rates were satisfactory. These rates were comparable to the few long-term studies in the literature.2, 4, 5 Although the shortage of donor organs is the major factor limiting the number of pancreas transplantations performed worldwide, donor age of 40 years or older is related to a reduced pancreas graft survival. For these reasons,
References (5)
Pancreas transplantation for patients with type 1 diabetes
Diabetes Care
(2003)- et al.
Analyses of pancreas transplant outcomes for United States cases reported to the United Network Organ Sharing (UNOS) and non-US cases reported to The International Transplant Registry (IPTR)
Clin Transplant
(2001)
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2017, NefrologiaCitation Excerpt :The survival time of renal transplant recipients has gradually increased because of the improved survival rate during the perioperative period and enhancements in treatment with anti-rejection drugs1–4; as a result, long-term complications and the quality of life of transplant recipients have recently received more attention.
Pancreas Transplantation: Small-Center Experience in Type 1 Diabetes Mellitus in a High-Incidence Region
2015, Transplantation ProceedingsCitation Excerpt :The total number of PT in Italy is approximately 60 per year [8], mainly because of the lack of suitable donors, especially for SPKT. Our results are comparable with those of more experienced Italian centers [7,9,10], and our experience confirms PT as a valid therapeutic option for diabetics, considering that PT patients do better than patients waiting for transplant and that mortality rate after more than 4 years in the waiting list group is greater than 50% [5]. The present retrospective study underlines that despite performing even fewer than 5 PT per year, graft and patient outcomes are similar to those in larger centers, giving this excellent therapeutic option to diabetics of the island and not penalizing them for insularity.
How reconstructive transplantation is different from organ transplantationand how it is not
2011, Transplantation ProceedingsCitation Excerpt :The Japanese Society for Lung and Heart Transplantation reported that the overall 5-year survival rate for deceased donor lung transplantation was 53.4% during the period 1998 to 2007.38 With improvements in organ preservation and technical aspects of the procedure and newer immunosuppressive protocols, survival rates of pancreas transplant grafts at 1 year have risen from 76% (1987–1992) to 85% (2001–2003) for simultaneous pancreas-kidney transplantation, with some individual centers reporting survival rates over 90%.39,40 Also, 1-year survival rates for pancreas after kidney (from 57% to 79%) and for pancreas transplantation alone (from 55% to 76%) have increased over this time span.28,41,42
Etiologic Agents of Bacteremia in the Early Period After Simultaneous Pancreas-Kidney Transplantation
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