Liver transplantationComplicationThe Burden of Chronic Kidney Disease in Long-Term Liver Transplant Recipients
Section snippets
Materials and Methods
This study included all adult patients (18 years of age or older) who received OLT at The Mount Sinai Medical Center from January 1997 to December 1999. The cutoff date for our analysis was January 1, 2005. A total of 502 OLT were performed during this period, and 284 patients (57%) were alive. Of the 284 survivors, 231 patients who were regularly followed at our post-OLT clinic were included in the study. Preoperative variables analyzed were: age, sex, race, body mass index (BMI, defined as
Patient Population
The median follow-up was 73 months (range, 60 to 84 months). There were 231 patients in the study and the patient demographics are shown in Table 1. There were 147 men (64%) and 84 women (36%), Caucasian (67%) and African-American (16%), with a mean age of 56 ± 12 years. The indications for OLT were: hepatitis C virus (HCV; n = 111), primary biliary cirrhosis (n = 32), alcoholic liver disease (n = 23), hepatitis B virus (n = 23), cryptogenic cirrhosis (n = 16), autoimmune hepatitis (n = 10),
Discussion
In this retrospective cohort study of stable OLT patients followed at our center, we found a very high incidence of CKD. Although CKD is common in long-term OLT recipients, previous studies have not clearly defined the exact incidence. In our study, only 10% of OLT recipients had a GFR of more than 90 mL/min, and the mean GFR for the entire population was 56 mL/min (stage III CKD). Hypertension was significantly more prevalent in the CKD group and appeared more difficult to control. These
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