Kidney transplantationOutcomeComparison of Outcomes of Living and Deceased Donor Kidney Grafts Surviving Longer Than 5 Years in Korea
Section snippets
Patients
From February 1995 to August 2003, 561 kidney transplantation cases were performed yielding 532 cases after excluding pediatric multi-organ procedures and retransplantations.
Estimated Glomerular Filtration Rate
The most recently advocated formula for calculating the glomerular filtration rate (GFR) is from the Modification of Diet in Renal Disease Study Group.9 The commonly used formula estimates GFR using 4 variables: serum creatinine, age, race, and gender. The equation has been validated in patients with chronic kidney disease.
Results
Among 532 kidney transplantation cases 216 kidneys were from deceased donors and 316 from living donors. Patient characteristics are described in Table 1. Recipients showed no difference in age, gender, or cause of renal failure. Donors were younger in the DDKT group (31.3 vs 38.9 years; P < .05). There were more male donors in the DDKT group compared with the LDKT group (73.4% vs 53.8%; P < .05). Deceased donors showed a greater fraction of HLA mismatches than living donors. Survival analysis
Discussion
In the early days of organ transplantation, the emphasis of clinicians and researchers was on prevention of acute rejection episodes to achieve improved short-term graft survivals. Now that these early goals have been met with effective immunosuppression, attention is slowly turning to long-term issues associated with transplantation.
Recently articles have reported long-term morbidity and mortality of transplantation. Matas et al10 identified a relatively steady rate of graft loss among 10-
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Cited by (19)
Analysis of Risk Factors for Delayed Graft Function After Kidney Transplantation
2022, Transplantation ProceedingsCitation Excerpt :Donor type and high hemoglobin concentration before kidney transplantation were significant risk factors for DGF in variable selection logistic regression analysis. This higher incidence of DGF in deceased-donor kidney transplantation in comparison to that of living-donor kidney transplantation is consistent with findings from several previous studies [11–14]. The goal of this study was to examine novel risk factors that can cause DGF.
A descriptive analysis of non-human leukocyte antigens present in renal transplant donor-recipient pairs
2021, Transplant ImmunologyCitation Excerpt :The UK has successfully paved the for international adoption of deceased after circulatory death (DCD) and brain death (DBD) donors, expanded criteria donors (ECD), into normal practice [6,7]. ECD were once considered to be an inferior transplant but evidence now suggests similar graft and patient survival when compared with ‘standard criteria’ deceased donor transplants [8]. These interventions to practice and policy increase the size of the donor pool.
Higher Renal Allograft Function in Deceased-Donor Kidney Transplantation Rather Than in Living-Related Kidney Transplantation
2018, Transplantation ProceedingsCitation Excerpt :This finding is contrary to some published studies [3,14]. Schwarz et al [14] found that LDKT recipients had a better early (6 weeks after transplant) and late (1 year after transplant) renal function than DDKT recipients, While Lee et al [3] found that among kidney grafts surviving over 5 years, there was no difference in survival or serum creatinine levels at 5 and 10 years between DDKT and LDKT grafts. In this study, the inferior eGFR might be attributed to donor characteristics.
Urinary mRNA analysis of biomarkers to epithelial mesenchymal transition of renal allograft
2018, Nephrologie et TherapeutiqueCitation Excerpt :In our study, factors such as the gender and the age of the recipients did not seem to affect the graft survival. Other studies have shown that living donor kidney had higher graft survival and lower acute rejection rates compared with deceased donor organs [21–23]. Moreover, this research showed that the transplantation from a living donor contributes to the reduction of the shortage of transplants; it allows a better survival rate and a long-term renal function of the graft.
Rewards to increase living kidney donation: The state of the art
2019, NefrologiaEchocardiographic Pulmonary Hypertension Predicts Post-transplantation Renal Allograft Failure
2017, Transplantation ProceedingsCitation Excerpt :Data were extracted from the TCDB and by medical record review. Patient characteristics including age, sex, race/ethnicity, body mass index (BMI), and factors previously reported to affect renal transplantation outcome, including cytomegalovirus (CMV) status and transplantation type (live vs deceased donor), were collected from the TCDB [14,27–29]. Additional risk factors for PH, including systemic hypertension, smoking history, diabetes mellitus, chronic obstructive pulmonary disease (COPD), and connective tissue disease were collected from the medical record.