Renal transplantationComplication: RenalRenalase, A Novel Regulator of Blood Pressure, Is Predicted by Kidney Function in Renal Transplant Recipients
Section snippets
Materials and Methods
These studies were performed on 80 kidney allograft recipients (58 males). Before transplantation, all of the recipients were on renal replacement therapy. The immunosuppressive regimen of kidney transplant recipients consisted of a calcineurin inhibitor in combination with mycophenolate mofetil, a mammalian target of rapamycin inhibitor, or prednisone. All subjects maintained sufficient stable graft function, showing no clinical signs of rejection or inflammation. Each subject gave informed
Results
Clinical and biochemical data of kidney allograft recipients are shown in Table 1. The mean serum renalase among recipients was significantly higher compared with the control group (6.72 ± 4.50 µg/mL vs 3.86 ± 0.73 µg/mL; P < .001). In kidney transplant recipients renalase correlated with age (r = 0.29; P < .05), time after transplantation (r = 0.34; P < .01) and systolic blood pressure (r = 0.28; P < .05; Fig 1) as well as diastolic blood pressure (r = 0.27; P < .05), serum creatinine (r =
Discussion
We observed that renalase was significantly higher among kidney transplant recipients compared with healthy volunteers. In addition, renalase content was related to kidney function, age, time after transplantation, serum phosphate, and blood pressure. On multiple regression analysis, renalase level was predicted independently by age, kidney function, time after transplantation, and diastolic blood pressure.
The connection between renalase and hypertension was demonstrated by Zhao et al12 in the
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Cited by (55)
The enzyme: Renalase
2017, Archives of Biochemistry and BiophysicsIncreased serum renalase in peritoneal dialysis patients: Is it related to cardiovascular disease risk?
2017, NefrologiaCitation Excerpt :In agreement with this finding, other studies also reported higher levels of serum renalase in PD and hemodialysis patients than in healthy volunteers, which were correlated with residual renal function.9,10,15,16 Furthermore, serum renalase levels were negatively correlated with glomerular filtration rates and increased in a graded fashion from CKD stage 2–5 in both CKD and kidney transplant patients.11,17,18 Since renalase is an amine oxidase that metabolizes circulating catecholamines and reduce their plasma levels, experimental and genetic studies proposed a protective effect of renalase in regulation of blood pressure and development of cardiovascular complications in kidney disease patients.
Human urinary renalase lacks the N-terminal signal peptide crucial for accommodation of its FAD cofactor
2015, International Journal of Biological MacromoleculesCitation Excerpt :Decreased renalase levels in patients with end-stage renal disease (ESRD) reported by the Desir's group [1,4] suggest that the development of hypertension in this category of patients may be well attributed to decreased renalase secretion by sick kidneys. The latter is especially important in the context of increased renalase levels in blood of kidney transplant patients [12,14,15], which have even higher renalase levels than donors donating the kidney to corresponding recipients [12]. However, renalase deficiency in circulation of ESRD patients [1,4] and high renalase levels in kidney transplant patients or hemodialysis patients [12,14,15] cannot account for the mechanism of (hypotensive?)
Renalase, kidney and cardiovascular disease: Are they related or just coincidentally associated?
2015, Advances in Medical SciencesCitation Excerpt :Therefore it would be worth to assess renalase before and after unilateral and bilateral nephrectomy as proof-of-concept study. So far in the published studies using commercially available assay, renalase levels were related to the kidney function [59–69] in just opposite manner as it would be expected from the landmark studies of Xu et al. [5]. In patients on renal replacement therapy in a form if either peritoneal dialysis or hemodialysis renalase was related to residual renal function [63,64].