Thoracic transplantationComplicationsRenalase and Endothelial Dysfunction in Heart Transplant Recipients
Section snippets
Patients and Methods
The 130 patients who had undergone their first OHT in a single institution, are described in Table 1 All of them were transplanted using the Shumway-Cooley-Brock technique. Prior to OHT the serum creatinine in all patients was below 162 μmol/L (less than 1.8 mg/dL). In 20% of them induction therapy included antithymocyte globulin (1.25 mg/kg/day) administered for 3 consecutive days. Lymphocyte subpopulations were monitored during this time by flow cytometry. The immunosuppressive regimen of
Results
Clinical and biochemical data of heart allograft recipients are shown in Table 1 Their mean serum renalase values were significantly higher compared with the control group: 8.41 ± 5.47 μg/mL versus 3.86 ± 0.73 μg/mL respectively (P < .001). Renalase correlated weakly with time after transplantation (r = 0.22, P < .05) and TRAIL (r = −.21, P < .05); moderately with age (r = .25, P < .01), ejection fraction (r = −.26, P < .01); and strongly with erythrocyte count (r = −0.42, P < .0001),
Discussion
We have shown renalase to be related, on univariate analysis to markers of endothelial cell injury and inflammation. However, the only predictor of renalase was serum creatinine on multiple regression analysis. Renalase was significantly higher among heart transplant recipients compared with healthy volunteers. In our previous study we observed clinically significant CKD (estimated GFR < 60 mL/min/1.73 m2) among 62.57% and 61.96% of heart allograft recipients according to MDRD and CKD-EPI
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Cited by (18)
Elevated renalase levels in patients with acute coronary microvascular dysfunction – A possible biomarker for ischemia
2019, International Journal of CardiologyCitation Excerpt :Renalase is linked with factors associated with endothelial dysfunction, such as hypertension, insulin resistance and diabetes. More recently, renalase has also been found to have an anti-inflammatory and anti-apoptotic effect released in response to ischemia [12]. Given the proposed mechanism of inflammation in CMD pathogenesis [13], we conducted an exploratory analysis to assess the relationship between renalase, inflammatory markers and acute chest pain.
Increased serum renalase in peritoneal dialysis patients: Is it related to cardiovascular disease risk?
2017, NefrologiaCitation Excerpt :They found that renalase had a positive correlation with erythrocyte sedimentation rate but a negative correlation with albumin. Among heart transplant recipients, renalase was correlated weakly with time after transplantation and TRAIL (TNF-Related Apoptosis Inducing Ligand); and strongly with kidney function, IL-6 and Von Willebrand factor.26 To the best of our knowledge, this is the first report describing a relation between renalase and CRP in PD patients.
The catalytic function of renalase: A decade of phantoms
2016, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :Moreover, in 2010, Pandini et al. reported that renalase yielded no added H2O2 production in the presence of catecholamines when compared to the appropriate controls [23] and this same group later showed that NAD(P)H does not contribute to catecholamine consumption either [9]. Despite these apparently sound refutations, the majority of renalase researchers continue to publish under the assumption that catecholamine catabolism is the function of this enzyme [1,3–5,12,15,24–50]. The renalase gene was identified from a survey of the 2003 mammalian gene project library.
Renalase does not catalyze the oxidation of catecholamines
2015, Archives of Biochemistry and BiophysicsCitation Excerpt :However, the flawed initial in vitro evidence and counter evidence have been insufficient to quell the passive consensus that the function of renalase is to oxidatively consume catecholamine neurotransmitters from blood. Consequently, the early claims for catecholamine oxidase activity continue to be adduced and correlated with a wide variety of physiological measurements [2–7,9,15–40]. We recently demonstrated that 2-dihydroNAD (2DHNAD(P)) and 6-dihydroNAD(P) (6DHNAD(P)), both isomers of β-NAD(P)H (4DHNAD(P)), rapidly reduce the FAD2 coenzyme of renalase (230 s−1 for 6DHNAD, 850 s−1 for 2DHNAD) and in doing so become oxidized to β-NAD(P)+.
The effect of bilateral nephrectomy on renalase and catecholamines in hemodialysis patients
2021, International Journal of Environmental Research and Public Health