9th Congress of the Andalucian Transplantation SocietyKidney transplantationAssessment of the Renal Function in Potential Donors of Living Kidney Transplants: Expanded Study
Section snippets
Materials and Methods
We have evaluated 105 potential living kidney donors from April 2011 to December 2014 in the Virgen del Rocio University Hospital. The mGFR has been done by the clearance of Cr-51-EDTA and the eGFR by CCr in 24-hour urine and serum creatinine–based formulas before donation as part of the screening program.
Results
From the 105 potential living kidney donors studied, 69 were females (65.7%), with an average age of 47.65 ± 10.94 years. Mean body area 2.04 ± 0.54 m2, urinary volume in 24-hours for the CCr was 1804.34 ± 767.6 mL/min with 92 (87.6%) valid samples to determine and average CCr of 130.78 ± 49.07 mL/min/1.73 m2. The mGFR mean was 96.22 ± 16.44 mL/min/1.73 m2 by EDTA-Cr51. eGFR mean according to the Cr-based formulas was: Cockcroft-Gault, 106.57 ± 22.42 mL/min/1.73 m2; MDRD-4, 100.14 ± 18.51;
Discussion
In the last decades both the average age of living donors and their cardiovascular comorbidity (advanced age, prehypertension, blood hypertension, obesity level I, and hydrocarbonated intolerance) have constantly increased due to new requirements for the inclusion criteria. These potential donors present more long-term risk of progressively losing their renal function after donation. Therefore, a more precise and rigorous evaluation of their kidney function is recommended, although nowadays no
References (19)
- et al.
Trends in organ donation and transplantation in the United States, 1997-2006
Am J Transplant
(2008) - et al.
Living donor kidney transplantation in a global environment
Kidney Int
(2007) - et al.
Measured and estimated GFR in healthy potential kidney donors
Am J Kidney Dis
(2004) - et al.
Geometric method for measuring body surface area. A height-weight formula validated in infants
J Paediat
(1978) Recomendaciones de la Sociedad Española de Nefrología (S.E.N.) y de la Organización Nacional de Trasplantes (ONT) sobre trasplante renal de donante vivo
Nefrología
(2010)- et al.
Living-donor kidney transplantation: a review of the current practices for the live donor
J Am Soc Nephrol
(2005) - et al.
The science of stewardship: due diligence for kidney donors and kidney function in living kidney donation— evaluation, determinants, and implications for outcomes
Clin J Am Soc Nephrol
(2009) - et al.
Effect of age, sex, and glomerular filtration rate on renal function outcome of living kidney donors
Transplantation
(1995) - et al.
Performance of the Modification of Diet in Renal Disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease
J Am Soc Nephrol
(2005)