National Congress of the Spanish Society of TransplantationOrgan retrieval and preservationStatic Cold Storage vs Ex Vivo Machine Perfusion: Results From a Comparative Study on Renal Transplant Outcome in a Controlled Donation After Circulatory Death Program
Section snippets
Material and Methods
Prospective observational paired study of kidney transplants from donors after controlled cardiac arrest performed at the Marqués de Valdecilla University Hospital during the period from September 2014 to December 2017.
One kidney from each pair was preserved on ice and transplanted first within the next few hours following procurement (Group A) while the contralateral kidney of the same pair was machine-perfused with a LifePort device (Organ Recovery Systems) and transplanted the day after
Results
During the study period, a total of 12 cDCDs were identified, resulting in 24 renal grafts procured from those donors and transplanted at our center. Cold ischemia time was 6h on average in Group A and 19.9h on average in Group B.
The main characteristics of donors are detailed in Table 1. Twenty-five percent of donors fulfilled the criteria for expanded criteria donors. Both groups were comparable with respect to recipients' characteristics. Cold ischemia time was significantly longer in Group
Discussion
Every year the proportion of cDCDs gains more weight, which contributes to increasing the number of organs eligible for transplantation. Several series have shown that the main disadvantage for using renal grafts from such cDCD donors as compared to DBD donors is the higher rate of delayed graft function, with advanced donor age and prolonged cold ischemia time being identified as extra major risk factors [12].
Ex vivo machine perfusion might offer a solution to this problem, as it might allow
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This work was supported by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, Fondo de Desarrollo Regional Europeo (Red de Investigación de Enfermedades Renales “RedInRen” RD16/0009/0027).