Original investigationProtein catabolic rate over lean body mass ratio: A more rational approach to normalize the protein catabolic rate in dialysis patients
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Cited by (30)
Nutritional management of maintenance hemodialysis patients
2021, Nutritional Management of Renal Disease, Fourth EditionHemodialysis Centers Guide 2020
2021, NefrologiaCitation Excerpt :On the other hand, nPCR may be underestimated due to the influence of the permeability of the dialyzer, the amount of blood, dialysate flow, and the distribution of urea in obese, malnourished or edematous patients. In contrast, nPCR may be overestimated by the posterior urea rebound following dialysis333–335. In hemodialysis units there are patients who in addition to renal failure suffer other concomitant disease conditions requiring follow-up and special monitoring.
Higher convection volume exchange with online hemodiafiltration is associated with survival advantage for dialysis patients: The effect of adjustment for body size
2016, Kidney InternationalCitation Excerpt :Dialysis patients are relatively sedentary, and greater muscle mass generally associates with greater physical activity and, as such, increased protein break down and metabolic rate.31 Re-analysis of the HD study showed that patients with greater body surface area, and by analogy muscle mass,32 benefited from a greater dose of dialysis when their dialysis prescription was adjusted for body surface area.24,33 This would support our analysis that the associated survival advantage for higher convective doses are observed when the convective dose is adjusted according to body surface area or total body water, surrogate estimates of lean body mass, rather than body size estimates more related to fat mass.34
The Saga of Two Centuries of Urea: Nontoxic Toxin or Vice Versa?
2014, Seminars in NephrologyCitation Excerpt :These observations lead to the establishment of directly applicable formulas to estimate PNA from UNA in dialyzed patients, but these values are accurate only in the steady-state patient in whom there is no positive or negative N accumulation.43 The rate of protein metabolism is associated with body size, so that comparability across patients is possible only after normalization for body weight which depends on the chosen measure (eg, lean body mass, total body water mass, dry body weight).44 Normalizing actual body weight can be misleading in malnourished, obese, or edematous patients, in whom using edema-free body weight therefore is preferred.42
Prealbumin is associated with visceral fat mass in patients receiving hemodialysis
2013, Journal of Renal NutritionCitation Excerpt :All measurements were made in duplicate using the average of these values for calculations. We used normalized protein catabolic rate (nPCR) (grams per kilogram per day) calculated from dialysis kinetic modeling during the month that body composition was measured as a valid surrogate for dietary protein intake23 and separately analyzed the determinants of albumin and then of prealbumin by multiple stepwise regression. Continuous variables were expressed as mean ± standard deviation and were compared with the Student t test or analysis of variance when appropriate.