Journal Information
Vol. 30. Issue. 1.January 2010
Pages 1-142
Vol. 30. Issue. 1.January 2010
Pages 1-142
DOI: 10.3265/Nefrologia.pre2010.Jan.10227
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A case of IgD lambda multiple myeloma with acute kidney injury
Mieloma múltiple IgD lambda con fracaso renal agudo. A propósito de un caso
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Tania Monzón Vázqueza, A.. Rodríguez Morenoa, P.. Delgado Condea, J.. Delgado Domíngueza, A.. Gomis Coutoa, A.. Barrientos Guzmána
a Servicio de Nefrolog??a, Hospital Cl??nico San Carlos, Madrid, Madrid, Espa??a,
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Dear Editor,

Monoclonal gammopathies include multiple clinical entities characterised by clonal proliferation of plasma cells that produce a homogeneous monoclonal paraprotein.1 To identify this protein serum immunoelectrophoresis or immunofixation need to be used.1 These monoclonal gammopathies can be classified as malignant, uncertain, idiopathic or transitory (the latter can occur in patients undergoing kidney transplantation due to immunosuppressive therapy, especially in older age).1 Multiple myeloma or Kahler’s disease is the prototype of malignant monoclonal gammopathy and is the most frequent neoplasm in plasma cells.1 It occurs mainly in elderly males (60-65 years) and its clinical features include bone, kidney, neurological, and, of course, haematological disease. Kidney function is impaired in 50% of patients at the time of diagnosis.2 It may be seen with tubular and/or vascular glomerular injury.2 Kidney involvement is the single most influential factor in poor prognosis and in 50% of cases is triggered by hypercalcaemia.1 The second mechanism of kidney injury is due to excessive production of immunoglobulins and/or light chains (Bence-Jones proteinuria) which are filtered by the glomeruli and saturate the kidney’s ability to absorb by the proximal tubule and catabolise in the lysosomes.2

We report the case of a man aged 84 who attended emergency due to poor health, anorexia and weight loss during a month. His background  revealed a history of hypertension and coronary artery disease. The physical examination showed a tendency to hypotension with discrete signs of dehydration without other relevant findings. The blood test gave: Hb 8.9g/dL, platelets 67,000L, leukocytes 7,700 per µL, creatinine 12mg/dL, urea 250mg/dL, K 6.7mEq/L, HCO39mEq/L. Abdominal ultrasound displayed both kidneys of 12cm with good corticomedullary differentiation and without signs of obstructive uropathy. On one occasion, a proteinogram in blood and urine was requested in the ward, which detected an IgD lambda monoclonal peak in blood of 0.89g/dL and urine of 1.68g/24 h. 60-90% infiltration of plasma cells was detected in the bone marrow study. Chemotherapy with bortezomib, melphalan and steroids is prescribed after diagnosis of IgD myeloma with cast nephropathy (or myeloma kidney). Inclusion in a haemodialysis programme was requested urgently. After 6 months, there was no objective improvement of kidney function.

This case is interesting not so much for pathology, but for one of its subclasses. IgD monoclonal gammopathy represents 1% of all myelomas, compared with IgG and IgA myelomas, which constitute 53 and 28% respectively of the total.1 The IgD myeloma takes a characteristically more aggressive course, and is associated with increased kidney disease rate (virtually 100% of the cases have Bence-Jones proteinuria).3,5 Myeloma clinical suspicion must always be present in the differential diagnosis of any cases of acute kidney injury, especially in elderly patients with a history of constitutional syndrome.

Bibliography
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Farreras Valent?? P, Rozman C. Medicina Interna (15.?? ed.). Madrid: Elsevier, 2004;2:1758-64.
[2]
Hernando Avenda??o L, Aljama Garc??a P, Arias Rodr??guez M. Nefrologia Cl??nica (3.?? ed.). Madrid: Editorial M??dica Panamericana, 2009;450-9.
[3]
Lin TL, Shih LY, Dunn P, et al. Inmunoglobulin D multiple myeloma. Chang Gung Med J 2000;23(8):451-7. [Pubmed]
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Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma. Review of 133 cases. Arch Intern Med 1975;135(1):87-93.
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Qiao SK, Zhang XL, Wang FX, Pan L. Inmunoglobulin D lambda multiple myeloma: a case report. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007;15(3):643-6. [Pubmed]
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