Journal Information
Vol. 36. Issue. 4.July - August 2016
Pages 333-464
Vol. 36. Issue. 4.July - August 2016
Pages 333-464
Letter to the Editor
DOI: 10.1016/j.nefroe.2016.09.011
Open Access
Paracoccus yeei peritonitis in peritoneal dialysis
Peritonitis causada por Paracoccus yeei en diálisis peritoneal
Visits
...
Aránzazu Sastre
Corresponding author
aranchasastre@hotmail.com

Corresponding author.
, Jose González-Arregoces, Igor Romainoik, Santiago Mariño, Cristina Lucas, Elena Monfá, George Stefan, Benjamin de León, Mario Prieto
Sección de Nefrología, Complejo Asistencial Universitario de León, León, Spain
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text
Dear Editor,

Peritonitis is defined as peritoneal inflammation caused by microorganisms, with the presence of cloudy peritoneal fluid, a leukocyte count of more than 100 per microlitre and leukocytes accounting for more than 50% of polymorphonuclear cells. It remains the most significant complication deriving from the dialysis technique itself. It is generally caused by Gram-positive skin bacteria such as Staphylococcus epidermidis and Staphylococcus aureus, or by enterobacteria and fungi. An intact peritoneum and the defence mechanisms of the mesothelium are probably the most significant barriers that help prevent the development of peritonitis. Prevention is the fundamental weapon, and the routes by which microorganisms enter the peritoneal cavity should be acted on: peritoneal access, connection systems, dialysis solutions and examinations that help enable infection.

Paracoccus yeei is a non-fermenting bacterium in the environment that is present in soil. It is the bacterium that caused the episode of peritonitis in the case that we are reporting.

Our case is a 46-year-old woman diagnosed with adult polycystic kidney disease, on a regimen of automated peritoneal dialysis for the last 3 years, with no prior episodes of peritonitis. The patient lived with a small dog she routinely take out for walks.

She visited the dialysis unit because she noticed cloudy fluid in the peritoneal effluent drainage. There was no fever or nausea, and her bowel movements were normal. She had slight abdominal discomfort, and an examination showed signs of peritoneal irritation. A peritoneal fluid cell count was performed and found 790leukocytes/mcl, with 75% polymorphonuclear cells. Samples were sent for the performance of a Gram stain, and cultures in blood culture and conventional media. A diagnosis of peritonitis was confirmed and treatment was started according to our site's protocol, with intraperitoneal vancomycin and ceftazidime. Empirical treatment of peritonitis was to be done with a combination of broad spectrum antibiotics targeting Gram-positive and Gram-negative microorganisms. The patient continued on an outpatient regimen, since her general condition was good, with daily self-administration of intraperitoneal ceftazidime and visits to the hospital to undergo follow-up cell counts. At 48h she received a positive culture in a blood culture medium for Paracoccus yeei. No bacteria were seen on a Gram stain, and a conventional culture was negative. Peritonitis results in morbidity and mortality, and is a cause of hospitalization in the most impaired patients. However, it can generally be treated on an outpatient basis, as in our case.

Paracoccus yeei was formerly classified as a eugonic oxidizer group 2 (EO-2) strain. In 2003, new molecular techniques identified this new species. It consists of small non-fermenting aerobic Gram-negative coccobacilli, with O-shaped morphology. The bacterium is catalase- and oxidase-positive. Its phenotype is identified by PCR and confirmed with 16S rRNA gene sequencing. It was identified for the first time in the peritoneal fluid in a peritoneal dialysis patient in Pennsylvania1 and subsequently anecdotally identified in other cases.2 It mainly affects immunodepressed patients and may cause skin infections,3 myocarditis,4 arthritis,5 keratitis and corneal graft rejection.6,7

It is found naturally in soil. Given that our patient had a small dog, we thought this could have brought the bacteria to her house, that the patient could have contaminated herself with it if she failed to comply with strict hand-washing and it could have passed to the peritoneum during connection.

The Paracoccus yeei bacterium is sensitive to beta-lactams, especially aminopenicillins and carbapenems, as well as third-generation cephalosporins. Intraperitoneal administration of antibiotics achieves improvement, as there is a higher concentration of bacteria at the infected site, and easily leads to eradication of the bacterium.

The course of our patient's peritonitis was good, with a gradual drop in leukocytes in the effluent from the time when she received the culture. Vancomycin was suspended and treatment was completed with ceftazidime for 14 days.

This bacterium is rarely identified in clinical samples. Animals such as a horse8 or, in our case, a dog may be the vehicle for human contamination.

We believe this to be the first reported case of Paracoccus yeei peritonitis in Spain.

References
[1]
M.I. Daneshvar, D.G. Hollis, R.S. Weyant, A.G. Steigerwalt, A.M. Whitney, M.P. Douglas, et al.
Paracoccus yeeii sp. nov (formerly CDCgroup EO-2), a novel bacterial species associated with human infection.
J Clin Microbiol, 41 (2003), pp. 1289-1294
[2]
D. Palamuthusingam, K.S. Tan.
The first case of Paracoccus yeeii species infection in Australia causing peritonitis in an APD patient.
Nephrology (Carlton), 19 (2014), pp. 116
[3]
G. Funke, R. Frodl, H. Sommer.
First comprehensively documented case of Paracoccus yeei infection in a human.
J Clin Microbiol, 42 (2004), pp. 3366-3368
[4]
M. Schweiger, P. Stiegler, M. Scarpatetti, A. Wasler, M. Sereinigg, G. Prenner, et al.
Case of Paracoccus yeei infection documented in a transplanted heart.
Transpl Infect Dis, 13 (2011), pp. 200-203
[5]
G. Coiffier, A. Gougeon, J.D. Albert, H. Le Bars.
Arthritis due to Paracoccus yeei.
Med Mal Infect, 43 (2013), pp. 254-255
[6]
J.C. Courjaret, M. Drancourt, L. Hoffart.
Paracoccus yeei keratitis in a contact lens wearer.
Eye Contact Lens, 40 (2014), pp. e21-e22
[7]
M.J. Kanis, J.J. Oosterheert, S. Lin, C.H. Boel, M.B. Ekkelenkamp.
Corneal graft rejection complicated by Paracoccus yeei infection in a patient who had undergone a penetrating keratoplasty.
J Clin Microbiol, 48 (2010), pp. 323-325
[8]
F. Wallet, N. Blondiaux, C.L. Foy, C. Loïez, S. Armand, D. Pagniez, et al.
Paracoccus yeei: a new unusual opportunistic bacterium in ambulatory peritoneal dialysis.
Int J Infect Dis, 14 (2010), pp. e173-e174

Please cite this article as: Sastre A, González-Arregoces J, Romainoik I, Mariño S, Lucas C, Monfá E, et al. Paracoccus yeei peritonitis in peritoneal dialysis. Nefrología. 2016;36:445–446.

Copyright © 2016. Sociedad Española de Nefrología
Idiomas
Nefrología (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.