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NefroPlus. Vol. 12. Núm. 01.Junio 2020
Páginas 1-105
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NefroPlus. Vol. 12. Núm. 01.Junio 2020
Páginas 1-105
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Propylthiouracil induced anti-neutrophil cytoplasmic antibody associated vasculitis: A case report and review of the literature
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Luísa Pereiraa, Ana Cabritaa, Anabela Guedesa, Teresa Jerónimoa, André Fragosoa, Sandra Sampaioa, Pedro Leão Nevesa,b
a Nephrology Department. Centro Hospitalar Universitário do Algarve. Faro. Portugal
b Medicine and Biomedical Sciences Department. Algarve¿s University. Faro. Portugal
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Abstract
The development of antineutrophil cytoplasmatic antibody (ANCA) during therapy with propylthiouracil (PTU) is not uncommon but occasionally has clinical significance. Risk factors associated with the development of ANCA associated systemic vasculitis when taking PTU have been described. We report and discuss a case with PTU-induced ANCA vasculi-tis with severe systemic manifestations, which improved with discontinuation of the antithyroid drug, plasmapheresis and on starting systemic immunosuppressive therapy.
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