Información de la revista
Vol. 31. Núm. 2.Marzo 2011
Contiene los Resúmenes de las Reuniones Científicas de la Sociedad Castellano-Astur-Leonesa de Nefrología
Páginas 0-240
Vol. 31. Núm. 2.Marzo 2011
Contiene los Resúmenes de las Reuniones Científicas de la Sociedad Castellano-Astur-Leonesa de Nefrología
Páginas 0-240
Acceso a texto completo
Relación entre leptina y mortalidad global y cardiovascular en pacientes en hemodiálisis
Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients
Visitas
...
, Juan José Díezb, Maurizio Bossolac, María José Fernández-Reyesd, Enrico Di Stasioc, Luigi Tazzac, Giovanna Lucianic, Rosa Codoceoe, Pedro Iglesiasb, Astrid Rodríguezd, Elena Gonzálezf, Rafael Selgasf
b Endocrinolog��a, Hospital Ram��n y Cajal, Madrid, Madrid, Espa��a,
c Servizio Emodialisi, Universit�� Cattolica del Sacro Cuore, Roma, Italia,
d Nefrolog��a, Hospital General de Segovia, Segovia, Segovia, Espa��a,
e Bioqu��mica, Hospital La Paz, Madrid, Madrid, Espa��a,
f Nefrolog��a, Hospital La Paz, Madrid, Madrid, Espa��a,
Información del artículo

Introducción: El objetivo del presente estudio ha sido evaluar la relación entre la leptina sérica y el cociente leptina/índice de masa corporal (IMC) con la enfermedad cardiovascular (ECV) prevalente y su influencia en la mortalidad global y en la mortalidad por ECV en pacientes en hemodiálisis (HD). Métodos: Se estudiaron 118 pacientes estables en HD (50 mujeres, edad mediana [recorrido intercuartílico], 65,1 [54,7-72,2] años). En todos los pacientes se cuantificó la concentración basal de leptina. La relación entre leptina y la mortalidad se evaluó mediante análisis de supervivencia y análisis de regresión de Cox. Resultados: El cociente leptina/IMC fue similar en pacientes con y sin ECV prevalente (0,65 [0,29-2,23] frente a 0,68 [0,29-1,49] ng·m2/ml·kg, respectivamente, NS). El análisis de regresión logística mostró que no existía una asociación independiente entre el cociente leptina/IMC y la enfermedad cardiovascular prevalente. Durante el seguimiento 52 pacientes fallecieron (44,1%). La ECV fue causa de muerte en 27 de 52 pacientes fallecidos (51,9%). El análisis de supervivencia y el análisis multivariante de Cox mostraron que no hubo relación significativa entre los niveles de leptina o el cociente leptina/IMC y la mortalidad global o por causa de ECV. Conclusión: Estos resultados no apoyan la hipótesis de que, en pacientes estables en HD, las concentraciones de leptina y el cociente leptina/IMC estén relacionados con la ECV prevalente. Más aún, el cociente leptina/IMC no parece ser un factor de riesgo de mortalidad en estos pacientes.

Palabras clave:
Enfermedad cardiovascular
Palabras clave:
Mortalidad
Palabras clave:
Enfermedad renal terminal
Palabras clave:
Hemodiálisis
Palabras clave:
Leptina

Background: We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD). Methods: 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis. Results: The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality. Conclusion: These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.

Keywords:
Cardiovascular disease
Keywords:
Mortality
Keywords:
End-stage renal disease
Keywords:
Hemodialysis
Keywords:
Leptin
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Nefrología

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