Journal Information
Vol. 44. Issue. 2.March - April 2024
Pages 119-312
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Vol. 44. Issue. 2.March - April 2024
Pages 119-312
Letter to the Editor: Comments on published article
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Acute interstitial nephritis following COVID-19 vaccination
Nefritis intersticial aguda tras la vacunación contra la COVID-19
Amnuay Kleebayoona,
Corresponding author

Corresponding author.
, Viroj Wiwanitkitb
a Private Academic Consultant, Samraong, Cambodia
b Honorary Professor, Dr. DY Patil Vidhaypeeth, Pune, India
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Dear Editor,

We would like to share ideas on the publication “A case of acute interstitial nephritis following the Pfizer-BioNTech COVID-19 vaccine.1” Flor Merino et al. reported a case and discussed on possible pathophysiological interrelationship. The COVID-19 vaccine can induce several atypical clinical adverse event and acute interstitial nephritis might be a possible one. However, it is necessary to recognize that there are other confounding factors that might result in the observed clinical problem. Without a complete laboratory investigation at pre-vaccination stage, it cannot rule out background medical problem. Also, the concurrent medical problem can occur in a COVID-19 vaccine recipient and might result in a renal problem. A good example is the concurrent dengue infection.2

Additionally, the patient might have prior or concurrent asymptomatic COVID-19 that can alter the immune response to the vaccine. Since asymptomatic COVID-19 is not uncommon and can be easily missed,3 the exact conclusion on the present case is still not final. It is necessary to have a complete investigation before a final conclusion.

Conflict of interest


J.C. de la Flor Merino, T. Linares Gravalos, M. Alonso-Riaño, P. Segura Cebollada, C. Albarracin Serra, E. Ruiz Cicero, et al.
A case of acute interstitial nephritis following the Pfizer-BioNTech COVID-19 vaccine.
A. Kebayoon, V. Wiwanitkit.
Dengue after COVID-19 vaccination: possible and might be missed.
Clin Appl Thromb Hemost, 27 (2021),
B. Joob, V. Wiwanitkit.
Letter to the Editor: Coronavirus disease 2019 (COVID-19) infectivity, and the incubation period.
J Prev Med Public Health, 53 (2020), pp. 70
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