NEFROLOGÍA. Vol. XXII. Suplemento 5. 2002 CONTENTS EIGHTH INTERNATIONAL SYMPOSIUM OF THE INSTITUTO «REINA SOFÍA» DE INVESTIGACIÓN NEFROLÓGICA In honour of Luis Hernando Barcelona, november 15-16, 2001 Guest Editors: F. Ortega, J. M. Campistol and J. Rodés I. INTRODUCTION F. Ortega, J. Baltar, M. García-Mendoza, T. Ortega and P. Rebollo II. VASCULAR REMODELING AND ANGIOGENESIS IN CIRCULATORY SYSTEM A) Participation of protein/phosphoinositide 3/Kinasa/Akt/eNOS pathway in angiogenesis and vascular remodeling M. Morales B) Role of cell cycle inhibitor p27 during vascular remodeling V. Andrés and A. Díez-Juan C) Role of fibroblast growth factors: relations structure-function in a peculiar family of proteins with broad spectrum activity G. Giménez III. CIRCULATORIES DISORDERS IN LIVER CIRRHOSIS A) Role of vascular nitric oxide in experimental liver cirrhosis N. M. Atucha, F. J. A. Nadal, D. Iyu and J. García-Estañ B) The molecular basis of sodium and water retention in experimental liver cirrhosis: acuaporins and sodium-dependent cotransporters in kidney of rats P. Fernández C) Role of hepatic stellate cells in the pathogenesis of portal hypertension F. Marra and M. Pinzani D) Pathophisiology of refractary ascites and hepatorenal syndrome V. Arroyo E) TIPS J. C. García-Pagán F) Aquaretics agents W. Jiménez G) Vasoconstrictors in the hepatorenal syndrome treatment R. Ortega, B. Calahorra and P. Ginès IV. UPDATING IN LIVER AND KIDNEY TRANSPLANTATION A) Kidney transplantation in HCV patients J. M. Campistol B) Combined liver and kidney transplantation L. Backman C) Renal failure in liver transplantation A. Rimola