Información de la revista
Vol. 33. Núm. 6.Noviembre 2013
Páginas 751-868
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 33. Núm. 6.Noviembre 2013
Páginas 751-868
DOI: 10.3265/Nefrologia.pre2013.Feb.11842
Acceso a texto completo
Comment on «Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure»
Comment on «Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure»
Visitas
...
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Texto completo

Dear Editor,

 

We read the article ”Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure” written by Larry M. Flores-Solís et al with interest.1 The authors concluded that the cut-off value proposed in this study for both cardiac troponin I (cTI) in patients with chronic renal failure (CRF) (stage 3 to 5) to diagnose acute coronary syndrome (ACS) is significantly different from that of the general population.1 Thank to the authors for their contribution of a study designed and documented successfully. We believe that these findings will guide further studies about cTI and creatine kinase MB(CK-MB) levels and CRF.

cTI and CK-MB levels in patients presenting with a suspected acute coronary syndrome help in the diagnosis of patients. It was proposed in a previous study that estimation of the glomerular filtration rate based on a normal creatinine level on admission provided important information on short-term prognosis2 and also it was recommended that glomerular filtration rate should be included in the risk assessment of patients with normal serum creatinine levels. But there is another issue which is the basement of the present study that patients with high creatinine levels due to CRF may be expected to have elevated cTI levels due to decreased glomerular filtration. However, cTnI is again the preferred biomarker for myocardial damage in patients with CRF3 as it is one of the least changed markers. When the patients with an elevated serum creatinine levels, especially those on dialysis treatment,4 are candidates for increased cardiovascular accidents, it is an additive factor that this situation may lead to some difficulties and can be more problematic in diagnosis of patients with a suspected acute coronary syndrome.

In addition to renal failure, cTnI levels may frequently be measured above normal values in several disease states in which myocardial necrosis is not a prominent aspect, especially in pulmonary embolism, heart failure, liver cirrhosis, septic shock, and arterial hypertension.5 Our challenge is on the issue that the study would be stronger if all the additional factors that might elevate cTI levels were mentioned in the study.

 

Conflicts of interest

 

The authors declare that they have no conflicts of interest related to the contents of this article.

Bibliografía
[1]
Flores-Sol??s LM, Hern??ndez-Dom??nguez JL, Otero-Gonz??lez A, Gonz??lez-Juanatey JR. Cardiac troponin I and creatine kinase MB isoenzyme in patients with chronic renal failure. Nefrologia 2012;32(6):809-18. [Pubmed]
[2]
Carda Barrio R, De Agust??n JA, Manzano MC, Garc??a-Rubira JC, Fern??ndez-Ortiz A, Vilacosta I, et al. [In-hospital prognostic value of glomerular filtration rate in patients with acute coronary syndrome and a normal creatinine level]. Rev Esp Cardiol 2007;60(7):714-9. [Pubmed]
[3]
Flores LM, Hern??ndez Dom??nguez JL, Otero A, Gonz??lez Juanatey JR. [Cardiac troponin I determination in patients with chronic renal failure]. Nefrologia 2006;26(1):107-12. [Pubmed]
[4]
Collado S, Coll E, Deulofeu R, Guerrero L, Pons M, Cruzado JM, et al. [Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors]. Nefrologia 2010;30(3):342-8. [Pubmed]
[5]
Nunes JP. Cardiac troponin I in systemic diseases. A possible role for myocardial strain. Rev Port Cardiol 2001;20(7-8):785-8. [Pubmed]
Idiomas
Nefrología

Suscríbase a la newsletter

Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.